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Three techniques used to study the cell surface of a human pathogen

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Method could reveal how cell surfaces may be altered by drugs or chemicals.

Hank Hogan

Researchers from Katholieke Universiteit Leuven in Belgium and from Pasteur Institute in Paris recently combined atomic force microscopy (AFM), x-ray photoelectron spectroscopy and secondary ion mass spectrometry to study the human fungal pathogen Aspergillus fumigatus. They found surface structure and surface chemical composition differences between mutants and wild-type versions of the microbe, results that agree with earlier biochemical data and that also provide insight into the cell wall architecture. The threefold characterization approach could produce information hard to get by...Read full article

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    Published: April 2008
    atomic force microscopyBasic ScienceBiophotonicschemicalsion mass spectrometryMicroscopyResearch & Technologyspectroscopyx-ray photoelectron spectroscopy

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