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Superresolution in two colors

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Researchers add more color to photoactivated localization microscopy.

Hank Hogan

Conventional optics can achieve a diffraction-limited resolution of only about a half a wavelength of the source light, which means that conventional microscopes have a maximum resolution of about 200 nm. In contrast, a technique called photoactivated localization microscopy (PALM) can achieve as much as 100 times better resolution. Researchers recently enhanced the technique by making it dual-color, enabling it to provide more information about how biomolecules interact. Triple-label imaging combines dual-label photoactivated localization microscopy (PALM) techniques with standard...Read full article

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    Published: February 2008
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    biomoleculesBiophotonicsFilterslensesmicroscopesMicroscopymirrorsOpticsResearch & Technologysuperresolution

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