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Fluorescence assays reveal DNA ligands

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Stopping the formation of telomeres — repetitive DNA sequences at the ends of chromosomes — likely will prevent cancer from surviving indefinitely. Because in vitro evidence suggests that telomere formation can be blocked by DNA structures called G-quadruplexes and because anything that obstructs telomere development probably will fight cancer, ligands that promote the assembly of G-quadruplexes could serve as cancer drugs. The structures consist of four DNA strands, stabilized by four guanines from the ends of the telomeres. The strands can come from one, two or four DNA...Read full article

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    Published: August 2007
    BiophotonicschromosomalDNAFrom The Journalsmoleculesspectroscopy

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