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High-Content-Screen Microscopy Enables Large-Scale Multiplex Image Analysis

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Technique provides reliable quantification in neuroscience drug discovery.

Jinhe Li and Min Hu, Abbott Laboratories

Quantitative analysis of cellular images is critical for investigating neuronal function and disease mechanisms in modern neuroscience drug discovery research. In the study of Alzheimer’s disease, neurotoxicity of β-amyloid peptide 1-42 (Aβ1-42) has been a primary focus of research for the past decade. Although β-amyloid has long been known to play a central role in Alzheimer’s disease, the underlying mechanisms still remain unclear. For example, although β-amyloid-peptide-mediated cell death has been observed in various cell-based models — in transgenic mice...Read full article

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    Published: July 2007
    Biophotonicsellular imagesFeaturesMicroscopyneuronal functionquantitative analysis

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