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Blood clot mechanics studied with AFM

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A specific region of the blood clot structural protein actively participates in clot stretching

David L. Shenkenberg

Blood clots are necessary to stop bleeding, but a clot in the wrong place can cause a heart attack or stroke. On one hand, very stiff clots are more likely to cause problems and potential death, but, on the other hand, clots that are too soft may not stop bleeding effectively. To understand why some clots become abnormally soft or stiff, it could help to study the mechanical properties of fibrinogen molecules, the precursors of the principal structural component of blood clots. A fibrinogen molecule contains a globular region at each end and one in its center. These three spherical...Read full article

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    Published: April 2007
    atomic force microscopyBasic ScienceBiophotonicsBlood clotfibrinogen moleculesMicroscopyResearch & Technology

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