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PI Physik Instrumente - Revolution In Photonics Align LW LB 3/24

Understanding atomic structures one molecule at a time

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Amanda D. Francoeur, [email protected]

Molecular structures may soon be exposed with the help of extremely bright ultrafast x-ray pulses tightly focused to cross a “particle beam” injector that fires micron-size droplets of water containing a single protein, virus or nanocrystal. The technique is so fast that it can capture diffraction patterns of atoms and biomolecules in motion. Combining these devices has heightened drug developers’ understanding of protein-drug bonding and cellular interactions for therapeutic drug development. Too big or too small X-ray crystallography, the current method for protein structure analysis,...Read full article

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    Published: October 2009
    Glossary
    diffraction
    As a wavefront of light passes by an opaque edge or through an opening, secondary weaker wavefronts are generated, apparently originating at that edge. These secondary wavefronts will interfere with the primary wavefront as well as with each other to form various diffraction patterns.
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    Arizona State UniversityASUatomic structureBasic ScienceBiophotonicsCCDcrystallizationDaniel DePonteDePontediffract and destroydiffractiondiffraction patternsFELfree electron lasergas dynamic virtual nozzleGDVNImagingJohn SpenceLawrence Berkeley National LaboratoryLBNLLCLSlensless imagingLinac coherent light sourcemolecular structuremoleculesnanoNews & Featuresparticle gunproteinprotein structure analysisSLACSpenceStanford Linear Accelerator Centerultrabrightultrafastviruswater dropletsx-rayx-ray pulses

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