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Visions of a better microarray

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Imagine a genomics or proteomics microarray that can be analyzed with surface-enhanced Raman scattering, a technique that can detect single molecules. What if the array could be designed to produce a maximally enhanced signal? Christopher J. Addison and Alexandre G. Brolo at the University of Victoria in British Columbia, Canada, have determined that surface enhancement is affected by varying the composition of nanoparticles on a glass slide, an early step toward establishing such a microarray. In their experiment, the scientists alternately deposited gold nanoparticles and a dithiol...Read full article

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    Published: November 2006
    Basic ScienceBiophotonicsMicroscopyResearch & Technologyspectroscopy

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