The first section of the 625-page work Optical Coherence Tomography: Principles and Applications is for nonphysical scientists, presenting the basic physics and mathematics used in this high-resolution imaging technique. The second section covers the physics and engineering of the technology, including the theoretical derivation of axial and lateral resolution generated with it. Among the topics discussed are photon entanglement, phase analysis, digital image processing techniques, dispersion analysis for tissue characterization, and the comparison of single- and dual-detector polarization-sensitive techniques. The last section details application to clinical imaging, covering oncology, cardiovascular medicine and musculoskeletal disease. Competing technologies are considered. Charts, diagrams, references and an index are included. Mark E. Brezinski; Academic Press, an imprint of Elsevier, Burlington, Mass., 2006; $95, €79.95.