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Electron microscopy helps define HIV’s spikes

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On each particle of HIV, there are scattered several spikes — composed of glycoprotein — that initiate the infection of healthy cells. The glycoprotein is a candidate target for potential vaccines against the virus; however, little is known about the structure and distribution of the spikes. Now Ping Zhu and his colleagues at Florida State University in Tallahassee and at the National Cancer Institute at Frederick and the National Institutes of Health in Bethesda, both in Maryland, have further defined the spikes using cryoelectron microscopy. With an electron...Read full article

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    Published: June 2006
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