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Imaging programmed cell death – live

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Margaret W. Bushee, [email protected]

Studying apoptosis, or programmed cell death, is imperative for understanding normal physiological functions as well as disorders such as cancer and neurodegenerative and autoimmune diseases. Being able to recognize the intracellular configurations of macromolecules that indicate apoptosis is essential for advancing biomedical science and applied medicine. Until now, however, it has not been possible to get an in-depth view of the apoptotic process. Only limited glimpses have been seen of the proteins, RNA, DNA and lipids that comprise the four major types of subcellular macromolecules....Read full article

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    Published: October 2010
    Glossary
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    acridine orangeAliaksandr V. KachynskiAndrey N. KuzminApoptosisapplied medicineArtem Plissautoimmune diseasebiomedical scienceBiophotonicsBioScancancerchemical bondcoherent anti-Stokes Rman scatteringdiffusionDNAenergyfluorescence recovery after photobleachingImagingin vivoInstitute for LasersintracellularkineticslipidmacromoleculeMargaret W. BusheeMicroscopyMultiplexnanoneurodegenerative diseaseNew YorkNewsnonlinear optical microscopynucleic acidnucleusParas N. PrasadPhotonics and Biophotonicsphysiological functionProceedings of the National Academy of Sciencesproliferationproteinreal-time imagingRNAtherapeutic drug administrationtwo-photon excitation fluorescenceUniversity at Buffalovibrational frequencyLasers

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