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Guide Star Sees Deep into Human Tissue

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ST. LOUIS, Feb. 14, 2011 — Astronomers have a neat trick they sometimes use to compensate for the turbulence of the atmosphere that blurs images made by ground-based telescopes. They create an artificial star called a guide star and use its twinkling to compensate for the atmospheric turbulence. Lihong Wang, the Gene K. Beare Distinguished Professor of Biomedical Engineering at Washington University in St. Louis, has invented a guide star for biomedical rather than celestial imaging, a breakthrough that promises game-changing improvements in biomedical imaging and light therapy. Wang's guide star is an...Read full article

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    Published: February 2011
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    phase conjugation
    The use of a reflective device, which can be fashioned from a variety of materials including gases, solids, dyes, aerosols, semiconductor crystals and plasmas, to replicate a laser beam by reversing the spatially dependent characteristics of its electrical field, and thus can cancel aberrations introduced into the beam after it leaves its source. Often called wavefront reversal. Nonlinear optical interactions such as three-wave and four-wave mixing, stimulated Brillouin scattering, stimulated...
    Americasartificial starsbiomedical imagingBiophotonicsguide starshologramsImagingLangevin Institutelight scatteringLight Sourceslight therapyLihong WangMathias Finkoptogeneticsphase conjugationphotothermal therapyResearch & TechnologySensors & Detectorstime-reversal mirrorstime-reversed ultrasonically encoded optical focusingultrasound imagingWashington UniversityLEDs

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