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Tracking molecules in live tissue at video rate

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New advances in microscopy using stimulated Raman scattering (SRS) have allowed researchers at Harvard University to capture blood cells being squeezed through capillaries. Previously, SRS microscopy could capture only about one image per minute, which was too slow for use in live animals or humans. The team of scientists was able to speed the collection of data by more than three orders of magnitude to provide video-rate imaging. SRS microscopy works by detecting intrinsic vibrations in chemical bonds between atoms. The optical technique complements MRI, which is suited to imaging...Read full article

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    Published: February 2011
    Glossary
    label-free
    Label-free refers to a technique or method that does not require the use of additional labels, tags, or markers to detect or identify specific components or entities. In various scientific and technological applications, labeling often involves attaching fluorescent dyes, radioactive isotopes, or other markers to molecules, cells, or structures of interest. However, in label-free approaches, detection or analysis is performed without the need for these additional labels. Common applications...
    magnetic resonance imaging
    An imaging technique used in radiology that is based on the principles of nuclear magnetic resonance (NMR) to produce high-quality images of the inside of the human body by imaging the nuclei of atoms within the body.
    AmericasatomsbackscatteringBiophotonicsBioScanblood cellscapillarieschemical bondsdata collectionendoscopyHarvard UniversityhumansImagingintrinsic vibrationslabel-freelaser lightlesionlight beamlipidlive animalslive tissuemagnetic resonance imagingMicroscopymigrationmoleculesMRINewsoptical techniqueOpticsorgansphotodetectorsproteinSensors & DetectorsskinSRSSRS microscopyStimulated Raman scatteringsubcellulartissuetumorsvideo ratevideo-rate imaging

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