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Finding a new pathway for antidepressants

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Compiled by BioPhotonics staff

A new fluorescence labeling technique that can monitor the reversible plasma membrane association of protein domains without the need for scanning, optical splicing or imaging has been identified by researchers. The method uses fluoxetine, an active ingredient in Prozac that suppresses the activity of the potassium channel protein TREK1, activity associated with mood regulation. TREK1 potassium ion channels, fluorescing green in these cultured neurons, have been linked to the regulation of emotions. Images courtesy of Isacoff group, UC Berkeley. Investigators at the University of...Read full article

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    Published: April 2011
    Glossary
    scanning
    The successive analysis or synthesizing of the light values or other similar characteristics of the components of a picture area, following a given method.
    Americasantidepressant drugsassaysBiophotonicsBioScanC-terminal domainCaliforniacytoplasmic regulatory domainsfluorescent dyesFluoxetineGFPgreen fluorescent proteinImagingLawrence Berkeley National Laboratorymood regulationNational Institutes of HealthneuronsNewsoptical splicingOpticspharmaceutical researchplasma membranespotassium channel proteinpotassium ionsProzacscanningTREK1University of California BerkeleyUS Department of Energy

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