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Molecules 'Light Up' Alzheimer's Roots

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HOUSTON, July 14, 2011 — A breakthrough in sensing at Rice University could make finding signs of Alzheimer's disease nearly as simple as switching on a light, and should help bring about better medications to treat the devastating disease. The lab of bioengineer Angel Martí is testing metallic molecules that naturally attach themselves to a collection of beta amyloid proteins, called fibrils, that form plaques in the brains of Alzheimer's sufferers. When the molecules, complexes of dipyridophenazine ruthenium, latch onto amyloid fibrils, their photoluminescence increases 50-fold. Because of their...Read full article

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    Published: July 2011
    Glossary
    photoluminescence
    The state of optically excited luminescence. Luminescence refers to the light emitted by excited atoms or ions as they decay to lower energy levels.
    Alzheimers diseaseAmericasAngel MartíBasic Sciencebeta amyloidBiophotonicsdipyridophenazine rutheniumfibrilsFLIMfluorescence lifetime imaging microscopyHoustonImagingmetallic moleculesMicroscopyphotoluminescenceplaquesResearch & TechnologyRice UniversitySensors & Detectorsthioflavin T

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