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Live-Imaging Technique Goes Sharper, Deeper, Faster

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PASADENA, Calif., July 29, 2011 — Researchers from the California Institute of Technology have developed a novel approach that could redefine optical imaging of live biological samples by simultaneously achieving high resolution, high penetration depth and high imaging speed. For modern biologists, the ability to capture high-quality 3-D images of living tissues or organisms over time is necessary to answer problems in areas ranging from genomics to neurobiology and developmental biology. The better the image, the more detailed the information that can be drawn from it. Three-dimensional live imaging of zebra fish...Read full article

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    Published: July 2011
    Glossary
    resolution
    1. In optics, the ability of a lens system to reproduce the points, lines and surfaces in an object as separate entities in the image. 2. The minimum adjustment increment effectively achievable by a positioning mechanism. 3. In image processing, the accuracy with which brightness, spatial parameters and frame rate are divided into discrete levels.
    AmericasBiophotonicsCaliforniaCalifornia Institute of TechnologyCaltechcamerasdevelopmental biologygenomicsGFPgreen fluorescent proteinImagingimaging speedindustriallight-sheet microscopyMicroscopyneurobiologyoptical imagingpenetration depthResearch & TechnologyresolutionSeth Ruffinsside illuminationThai Truongtissue imagingtwo-photon excitationWilly Supatto

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