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STED microscopy reveals how immune system attacks infected cells

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Ashley N. Paddock, [email protected]

A new stimulated emission depletion (STED) microscope has yielded unprecedented views of the immune system in action. The superresolution microscope shows how granules from natural killer (NK) cells pass through openings in the dynamic cell skeleton to destroy their targets: tumor and virus-infected cells. Understanding these biological events better may soon allow researchers to devise more effective treatments for inherited diseases that leave the immune system compromised. “From a biological perspective, the work defines a previously unappreciated regulatory hurdle that an...Read full article

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    Published: November 2011
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    AmericasBiophotonicsBioScancell-killilng moleculesChildrens Hospital of PhiladelphiadefenseF-actinfluorescencegranulesimmunological synapseJordan OrangeMicroscopynatural killer cellsNewsNK cell lytic organellesNK cellsOpticsPennsylvaniaprotein filamentsSTEDSTED microscopestimulated emission depletion microscopesuperresolutionsuperresolution microscopyLasers

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