URBANA-CHAMPAIGN, Ill., Jan. 14, 2014 — New understanding of secondary light emission by plasmonic nanostructures could lead to improvements in medical imaging.
Work by materials scientists and engineers at the University of Illinois at Urbana-Champaign presents an alternate description of secondary light emission from plasmonic nanostructures, which is typically described as two-photon absorption followed by fluorescence, as a resonant electronic Raman scattering process.
“Plasmonic nanostructures are of great current interest as chemical sensors, in vivo imaging agents and for photothermal therapeutics,” said David Cahill, professor and head of the Department of Materials Science and Engineering. “Applications in imaging and sensing typically involve the emission of light at a different wavelength than the excitation, or ‘secondary light emission.’ The interpretation of resonant secondary light emission in terms of fundamental processes has been controversial for 40 years.
Illustration of resonant electronic Raman scattering and resonant fluorescence. Courtesy of Jingyu Huang, University of Illinois.
“In this work, we point out that resonant electronic Raman scattering and resonant fluorescence may both be useful descriptions of the secondary emission,” Cahill said. “Better understanding of these principles and their limitations can result in improved biological and medical imaging modalities.”
Fluorescence is a process by which light of one color or wavelength is absorbed by a material, e.g., an organic dye or a phosphor, and then emitted as a different color after a brief interval of time. In Raman scattering, the wavelength of light is shifted to a different color in an instantaneous scattering event. Raman scattering is not common in everyday life, but is a critical tool for analytical chemistry.
“Light emission from plasmonic nanostructures at wavelengths shorter than the wavelength of pulsed laser excitation is typically described as the simultaneous absorption of two photons followed by fluorescence, which is used a lot in biological imaging,” said Jingyu Huang, first author of the paper that appears in PNAS.
However, we found that by modeling the emission as Raman scattering from electron-hole pairs can predict how the light emission depends on laser power, pulse duration and wavelength.
“Since we understand more of the mechanism of this kind of light emission, we can help to design the biological and medical imaging experiments better, and at the same time we can also have more insight into the broad background of surface-enhanced Raman scattering, which is also related to this kind of light emission,” Huang said.
In addition to Huang and Cahill, the paper’s authors include Wei Wang, Department of Materials Science and Engineering, and Catherine J. Murphy, Department of Chemistry and the Frederick Seitz Materials Research Laboratory.
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