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Optogenetics Heightens Whisker Sensitivity in Mice

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Researchers have heightened the sensitivity of mouse whiskers by using optogenetics to create gamma waves in the brain. A team from Brown University used pulses of blue light to manipulate inhibitory interneurons in the primary sensory neocortex of the mice, generating a gamma rhythm. The primary sensory neocortex controls the mouse’s ability to detect faint sensations via its whiskers. Mice sometimes naturally produce a 40-Hz gamma rhythm in their sensory neocortex, according to the researchers. The researchers said gamma waves could make typically difficult-to-perceive...Read full article

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    Published: August 2014
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    AmericasBiophotonicsBrown UniversityChristopher MooreoptogeneticsResearch & Technologygamma brainwavesgamma rhythmJoshua SiegleBioScan

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