Search
Menu
PI Physik Instrumente - Revolution In Photonics Align LW LB 3/24

Nanoconstructs Aid Ovarian Cancer Targeting

Facebook X LinkedIn Email
Newly developed nanostructures have proven to be effective vehicles for laser imaging and ablation of ovarian cancer cells.

A team from the University of California, Riverside, and the University of Texas said their approach facilitated near-infrared fluorescence imaging of the over-expression of human epidermal growth factor receptor-2 (HER2), as well as photothermal destruction of these cells in vitro.

“Multifunctional nanoconstructs were utilized to optically detect ovarian cancer cells followed by laser-based photodestruction of cancer cells,” said Dr. Baharak Bahmani of UC Riverside.

Flow cytometry and fluorescence microscopy allowed the researchers to look at the constructs’ molecular targeting and imaging capabilities against SKOV3 and OVCAR3 ovarian cancer cell lines. Continuous NIR laser irradiation at 808 nm was used to investigate the utility of those constructs.

The nanoconstructs used an NIR dye, indocyanine green (ICG), encapsulated within a polymer functionalized with monoclonal antibodies.

The researchers found that the functionalized nanoconstructs are more effective in targeting the HER2 receptor than nonencapsulated ICG and nonfunctionalized constructs.

The researchers said their findings could be applied to intraoperative detection, imaging and phototherapy of ovarian cancer nodules.

The research was published in Lasers in Surgery and Medicine (doi: 10.1002/lsm.22269).

For more information, visit www.ucr.edu.
Gentec Electro-Optics Inc   - Measure Your Laser MR

Published: October 2014
Glossary
nano
An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
phototherapy
Phototherapy is a medical treatment that involves the use of light to treat various conditions, particularly those related to the skin or mood disorders. There are different types of phototherapies, each tailored to address specific conditions: UV phototherapy: This form of phototherapy utilizes ultraviolet (UV) light to treat skin conditions such as psoriasis, eczema, vitiligo, and certain types of dermatitis. UV radiation can suppress the immune system and reduce inflammation, leading to...
Research & TechnologyLasersBiophotonicsAmericasnanophototherapycancerovarian cancerUniversity of CaliforniaRiversideUniversity of TexasBaharak BahmaniBioScan

We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.