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  • Imaging System Offers Clearer Tissue Visualization

Photonics.com
Mar 2014
WALTHAM, Mass., March 5, 2014 — Studying proteins and disease markers could get easier, thanks to a new high-throughput imaging system called Lamina.

A team at PerkinElmer Inc. designed the multilabel slide scanner to enable research pathologists to more easily analyze protein expression and the relationships between disease markers in formalin-fixed, paraffin-embedded (FFPE) tissue sections.

The device will provide a more comprehensive understanding of diseases for the development of more effective treatment and therapy, the researchers say.


A new high-throughput imaging system will make studying proteins and disease markers easier. Courtesy of PerkinElmer Inc.

This new system will offer improvements in real time during whole-slide scanning, which also enables clearer visualization of fluorescently labeled tissues. Users will be able to obtain more accurate information from histological specimens.

“The Lamina scanner can help research pathologists more effectively interpret their images by automating work flows and providing clearer and faster results,” said Jim Corbett, president of Diagnostics, Life Sciences & Technology at PerkinElmer. “These advanced digital pathology capabilities can help lead to a better understanding of disease.”

The system reduces interference from autofluorescence, an unwanted byproduct of tissue fixation, as well as fluorophore crosstalk, in which the signal from one fluorophore bleeds into multiple channels. Both of these effects obscure real signals, which can result in an incorrect assessment of a slide.

The scanner produces digital, whole-slide images of hematoxylin and eosin, immunohistochemistry, and immunofluorescence-labeled tissue sections and tissue microarrays.

For more information, visit www.perkinelmer.com.


GLOSSARY
fluorophore
Material that emits fluorescence.
immunofluorescence
The technique that uses light to detect and analyze the antibodies produced by a specimen stained with an organic dye.
scanner
1. A device used to trace out an object and build up an image. One of the most common of these types is video scanning. The scanning takes place inside the television tube as electrons, guided by electron optics, sweep linearly across a tube face coated on the inside with a phosphorescent material. A scanner can convert a paper drawing or photograph into pixels on a display screen. Scanners are also used to relay information in optical data processing. 2. A device that automatically measures or...
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