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BioPhotonics: December 2006

Finding Photonic Ways to Monitor Blood Sugar
Spectroscopic and fluorescence techniques might someday take the sting out of self-checking by diabetics. People afflicted with diabetes mellitus do not naturally produce enough insulin to process the sugars that they ingest into useful energy for their cells. Instead, they must regulate their sugar intake, increase their level of exercise and — if they are among the 5 to 10 percent...
Frequency Division Multiplexed Fluorescence Confocal Microscopy
High-speed, multichannel fluorescence confocal imaging can be achieved by encoding the spatial location information into the frequency domain. Fluorescence confocal microscopy is an important tool...
Dr. Stuart Yin, Pennsylvania State University
New Tools and Methods Accelerate Drug Discovery and Development
Microfluidics and optical imaging are bridging the productivity gap in drug development. The pharmaceutical industry is under intense pressure to improve the efficiency of drug discovery and...
Mark Roskey, Caliper Life Sciences Inc.

Fluorophores emit white light
Because intermolecular distances are small, Förster resonance energy transfer (FRET) measurements must be precise to determine whether molecules interact. Using a fluorophore that...
David L. Shenkenberg
Miniature endoscope captures 3-D images
An ultraminiature endoscope that offers three-dimensional imaging and enough flexibility to reach particularly delicate regions of the body has been developed by researchers from Harvard Medical ...
Michael A. Greenwood
Imaging chemotherapy’s effects on the brain
Breast cancer survivors who have endured mental fogginess and forgetfulness following chemotherapy can take some comfort in the fact that “chemo brain” has been validated as a...
Caren B. Les
Chemiluminescence gets a boost from microwaves
Chemiluminescence-based methods of detecting biological processes at the cellular level work well because most samples do not generate unwanted luminescence that must be filtered out. Using these...
Lynn M. Savage
Technique creates “islands” to isolate optical energy in skin
In 2005, Americans spent more than $300 million on almost 800,000 laser hair removal treatments, according to the American Society of Plastic Surgeons. Lasers also can be used to alter skin ...
David Shenkenberg
Raman spectroscopy detects bladder cancer
To localize a tumor in the bladder, doctors routinely perform a cystoscopy, a procedure that involves inserting a lensed, lighted tube into a patient to enable their search for potentially...
David L. Shenkenberg
GFP cages may lead to new robust fluorophores
Collaborative work among research groups at the University of Genoa, the University of Parma, and the University of Milano-Bicocca, all in Italy, has demonstrated that polyelectrolyte cages can...
Kevin Robinson
Photoacoustic detection shows its sensitive side
Detection of metastasis often proves to be difficult, either because investigation comes too soon in the development of tumor cells or because the cells have begun to disseminate away from the...
Lauren I. Rugani
MRI may directly detect neuronal electrical activity
Functional MRI is a noninvasive neuroimaging method that indirectly measures neuronal electrical activity by tracing localized changes in blood flow, blood volume and oxygenation levels associated...
Gwynne D. Koch
UVP Inc.
UVP Inc. of Upland, Calif., will distribute low-light imaging standards for Lux biotechnology ltd. of Edinburgh, UK, exclusively in North America and nonexclusively in Europe. The standards are...
Hologic Inc.
Hologic Inc., a provider of diagnostic and digital imaging systems directed toward women’s health, has dedicated a new European headquarters, service and parts depot, and training center in...
Invitrogen Corp.
Invitrogen Corp. of Carlsbad, Calif., will acquire Phillipsburg, New Jersey-based Sentigen Holding Corp., a developer of bioassay systems, in a cash transaction valued at $3.37 a share, or...
Cynosure Inc.
Cynosure Inc. has received FDA clearance for its Smartlipo system for laser-assisted lipolysis in which a laser fiber cannula is inserted into the skin and through the treatment area to cause fat...
The National Human Genome Research Institute
The National Human Genome Research Institute has awarded more than $13 million in research grants to speed the development of techniques that will reduce the cost of DNA sequencing and expand the...
Nikon Instruments
Nikon Instruments of Melville, N.Y., and California Institute for Quantitative Biomedical Research have opened a core microscopy imaging center at the University of California, San Francisco, to...
Mercury Computer Systems Inc.
Mercury Computer Systems Inc. of Chelmsford, Mass., and Brit Systems Inc. of Dallas have partnered to integrate and distribute the latter company’s radiological image management system. Under...
Siemens Medical Solutions
Siemens Medical Solutions of Malvern, Pa., has received a letter of approval from the FDA for its syngo Lung computer-aided detection device, designed to assist radiologists in the detection of...
Liquidmetal Technologies Inc.
In California, Liquidmetal Technologies Inc. of Lake Forest has entered into an exclusive licensing and development agreement with Biolase Technology Inc. of Irvine for medical lasers in the dental...
The Cooperative Institute for Coastal and Estuarine Environmental Technology
The Cooperative Institute for Coastal and Estuarine Environmental Technology has awarded $270,274 to two researchers to develop a tool for improved detection of microalgae. Hugh MacIntyre, senior...
BioVision Technologies Inc.
BioVision Technologies Inc. of Exton, Pa., a provider of scientific digital imaging products, has acquired the software code, distribution rights and specific assets related to IPLab for Macintosh...
Affymetrix Inc.
Affymetrix Inc. of Santa Clara, Calif., has announced that NimbleGen Systems Inc. of Madison, Wis., has obtained a nonexclusive, worldwide license to a number of its patents covering the...
Salvador Imaging
Salvador Imaging of Colorado Springs, Colo., has entered into a $1.9 million contract to design and produce digital cameras for a leading veterinary x-ray imaging supplier. The cameras will be...
Millipore Corp.
Millipore Corp., a provider of products and services for the improvement of productivity in the laboratory and in biopharmaceutical manufacturing, has opened a research and development center in...
NeuroMetrix Inc.
NeuroMetrix Inc. of Waltham, Mass., a medical device company, has signed an exclusive licensing agreement with EyeTel Imaging Inc. of Columbia, Md. The agreement allows the Massachusetts company to...
Leica Microsystems GmbH
Leica Microsystems GmbH of Wetzlar, Germany, has received approval from the FDA for its Leica FL800, a video angiogram device for viewing of intraoperative blood flow in the cerebral vascular ...
The NIH has completed its national network of eight Nanomedicine Development Centers as part of its nationwide Roadmap for Medical Research program. Staffed by multidisciplinary scientific teams...
Bio-Rad Laboratories Inc.
Bio-Rad Laboratories Inc. of Hercules, Calif., has announced its purchase of 2583%%Ciphergen Biosystems Inc.’s ProteinChip Systems business and rights to the Fremont, Calif., company’s...
Eastman Kodak Co.
Eastman Kodak Co. has submitted the final clinical trial data and test results necessary for FDA premarket approval of its computed radiography (CR) system for mammography. The DirectView CR...
Fairway Medical Technologies Inc.
Fairway Medical Technologies Inc. of Houston has received $3.8 million in federal funding to conduct Phase II research on optoacoustic breast and prostate cancer diagnostic methods. The NIH’s...
Olympus America Inc.
Olympus America Inc. of Center Valley, Pa., has acquired the assets of New York/New Jersey Scientific Inc. of Middlebush, N.J., which distributes and resells scientific instruments. Olympus...
Andor Technology
Andor Technology of Belfast, UK, has appointed 16468%%Gilden Photonics, also of the UK, as a distributor of its spectroscopy cameras and spectrographs within the UK.
LabSmith Inc.
LabSmith Inc. of Livermore, Calif., has teamed up with Micronit Microfluidics BV of Enschede, the Netherlands, to offer complete solutions for microfluidics research. The cooperative effort brings...

New insight into the cause of multiple sclerosis
In multiple sclerosis, inflammation in the central nervous system leads to unsheathing of the protective myelin that coats neurons, causing them to degenerate. Scientists have thought that the inflammation is caused by an immune response directed against the myelin. New research lends credence to this belief by revealing certain specifics of how the immune response occurs. The work could...
Nancy D. Lamontagne

Nanoparticles target brain tumors
Nanoparticles packed with high concentrations of a proven cancer-killing drug may provide a safer and more effective way to target brain tumors, researchers at the University of Michigan...
Grid technology enables electronic image sharing among hospitals
Digital Imaging and Communications in Media (DICOM) standards have helped create a uniform format for x-ray, CT, MRI and other medical images. Although the standards ease image analysis, doctors...
Mini mugs manufactured to hold microsamples
The first time people order espresso, they are usually surprised at the dainty dimensions of the porcelain cup in which it is served. But those cups are huge compared with the ones created...
Imaging the brain’s response to brand names
Scientists have observed through functional MRI that well-known product brand names have a strong, positive effect on the human brain, independent of the type of product or service being offered. ...

Biochip technology
Geared toward bioengineers, biotechnologists, and pharmacological and general bench researchers, Frontiers in Biochip Technology is a collection of manuscripts written by experts on emerging...
Histological techniques
The second edition of Cellular Pathology: An Introduction to Techniques and Applications is designed to serve as a textbook for students in biomedical science and other fields related to medicine....
Cell culture supplies
Millipore Corp. has released its “Multiwell Products Guide,” which presents tools for drug discovery research and sample preparation. The 40-page resource includes information on the...
Molecular imaging
An application overview titled “Molecular Imaging on the Odyssey” is available from Li-Cor Biosciences. The downloadable four-page, full-color brochure describes the Odyssey infrared...
Jasco Inc. has released a 12-page, full-color brochure that describes the features and benefits of its V-600 series UV-VIS/NIR spectrophotometers. Available in print and as a download, the document...
Biophotonics Book
Optical technologies, including microscopy and spectroscopy methods, are described in Biophotonics: Visions for Better Health Care. The 621-page volume represents a three-year research program...
Clinical MRI
The multimedia edition of Clinical Magnetic Resonance Imaging provides online access to the text and images of the three-volume, third-edition set, which is included in the package. The resource...
Optics Web sites
The Optical Society of America has launched enhanced Web sites to represent both its organization and its magazine Optics & Photonics News (OPN). The OSA portal features streamlined...
Cardiac CT
Written for cardiologists and radiologists, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease provides an overview of the use of computed tomography for assessing cardiac structure and...
Optics topics
The book Optics: Principles and Applications is geared toward engineering and physics students and professionals, detailing topics such as holography, geometric optics, Fourier transforms,...

Digital camera
Diagnostic Instruments Inc. has unveiled an enhanced Spot Xplorer XS digital camera system for biological imaging. Providing 14-bit megapixel images at up to 11 full frames per second, and as low as 4.5 e2 read noise for tracking rapid events, the system features dual-speed readout for maximum speed or lowest noise level. It delivers —42 °C regulated cooling for dark noise reduction...
SPOT Imaging Solutions
Perfusion system
A miniature perfusion system for exchanging or applying test solutions to microscopic samples during imaging or recording has been released by Bioscience Tools. It features digital, analog and...
Bioscience Tools
Fluorescence illumination
The Lumen 200 fluorescence illumination system from Prior Scientific Inc. employs a 200-W metal arc lamp that lasts 2000 h. The lamp is precentered for easy installation. The light can be connected...
Prior Scientific, Inc.
Multiwavelength illuminator
Available from Opto Technology Inc., the OTLA-0130 broadband illuminator incorporates a white LED along with a monochromatic LED die to expand the unit’s spectral output. Suitable for...
Opto Technology, Inc. (bought by Excilitas)
Multiphoton microscope
With the FluoView FV1000-MPE multiphoton laser scanning microscope system from Olympus America Inc., researchers can view living cells and tissues to a depth of several hundred microns without...
Olympus America Inc., Industrial Products Group
Imaging systems
The Spotlight 400 FT-IR and 400N FT-NIR imaging systems from PerkinElmer Inc. are designed to increase throughput and improve data quality of samples in laboratories that specialize in...
PerkinElmer Instruments
Quantitative imaging
The Lumazone imaging system from Roper Bioscience is offered in various models for quantitative measurements of chemiluminescence and fluorescence emitted by samples, including whole animals and...
Roper Bioscience
NMR spectrometer
The 400-MR nuclear magnetic resonance (NMR) spectrometer introduced by Varian Inc. is suitable for routine use in a variety of laboratories, including those in pharmaceutical, biotechnology,...
Photodetector amplifier
Opto Diode Corp. has announced the ODA-5W-100M photodetector amplifier combination with 100 megaohm gain, suitable for fluorescence, spectroscopy and low-light-level tasks where electrical noise...
Opto Diode Corporation
Microarray analysis
BioDiscovery Inc.’s aCGH (array comparative genomic hybridization) module for its ImaGene 7.0 microarray image analysis software can quantify chromosomal copy number and provide a chromosomal...
LED ringlight
The RL-9, a high-output LED ring-light from Orled, allows light from the LEDs to pass through a polarizing film before illuminating a reflective object, diminishing glare. Light bounces off the...
Electrophoresis software
Bio-Rad Laboratories Inc. is offering security edition software and a validation kit for its Experion automated electrophoresis system targeted toward biotechnology and pharmaceutical companies....
Bio-Rad Laboratories, Inc., Life Science Group
Secreted luciferase
The Ready-to-Glow secreted luciferase system from Clontech Laboratories Inc. is convenient for high-throughput screening because it does not require a cell lysis step. It was cloned from Metridia...
Video imaging module
Navitar Inc. has released a differential interference contrast module, a video imaging tool for inspecting semiconductor wafers, flat panel displays, diamonds, translucent biological samples and...
Navitar, Inc.
Laser safety goggles
Laservision GmbH has introduced lighter-weight absorbing polycarbonate filters for its frame-style Vision L-05 laser safety goggles. The temples can be adjusted to various angles and lengths to...
LASERVISION GmbH & Co. KG, Laser Safety Products
Nanoparticle counter
NanoSight Ltd. has launched a bench-top system that rapidly and easily sizes and counts individual nanoscale particles in suspension. The system, NanoSight LM20, has newly developed software that...
NanoSight Ltd.
Frame grabbers
National Instruments has released three PCI Express-based frame grabbers, supporting major digital camera buses. Suitable for machine vision, the NI PCIe-8255R can acquire data from IEEE-1394a and...
National Instruments Corp.
Programmable logic
The LC220 programmable logic controller from LabSmith Inc. provides synchronization for lasers and laboratory apparatus. With Windows- or LabView-based programming, it can be operated while...
LabSmith, Inc.
Image recognition
SVCell microscopy image recognition software from SVision LLC allows researchers to teach the computer to automatically detect, classify and analyze cellular phenotypes. Using a GUI, they can...
SVision LLC
LCDs, LED backlights
LCDs equipped with LED backlighting systems instead of conventional cold cathode fluorescent lamps are offered by Kyocera Corp. The lead- and mercury-free displays have applications in medical...
Kyocera Optec Co., Ltd.
Photon counter
Users of the id201 near-IR, single-photon detector from id Quantique SA can adjust the bias voltage, which controls detection efficiency. Photon detection probability at 1550 nm can be selected...
ID Quantique
EMCCD camera
The QuantEM:512SC is an electron-multiplying (EM) CCD camera from Photometrics with 16-bit quantitative stability. It provides single-molecule sensitivity for ratiometric analysis in time-course...
PLL synchronization
Toptica Photonics AG has added phase-locked-loop (PLL) synchronization electronics to its line of FemtoFiber scientific lasers. Femtosecond lasers now can be synchronized to synchrotrons,...
TOPTICA Photonics AG
GPCR profiling
Millipore Corp. offers the GPCR-Profiler service for characterizing lead compounds and screening focused G protein-coupled receptors (GPCRs). The package includes selectivity screening for...
EMD Millipore
CMOS cameras
The Go series digital color cameras from QImaging uses CMOS sensors and can be connected through a USB 2.0 interface. The cameras can be used for histological and pathological applications. The...
Magnetic beads
Bruker Daltonics Inc. has launched the ready-to-use ClinProt MB, a lectin affinity chromatography-lens culinaris agglutinin kit for glycoprotein analysis and clinical proteomics research. The...
Bruker Daltonics Inc.
Microscope system
The Axio Observer inverted microscope system from Carl Zeiss MicroImaging GmbH is an integrated research platform for cell observation, manipulation and analysis. The company says it can be...
Carl Zeiss MicroImaging GmbH
Digital cameras
Imperx Inc. has added two new cameras to its Lynx digital camera line. The IPX-16M3-G and the IPX-16M3-L offer fully programmable resolution, frame rate and exposure control. The cameras use a...
Imperx, Inc.
NIR spectrometer
Avantes BV has unveiled the AvaSpec-NIR256 spectrometer, available with two InGaAs detector types — an uncooled version for applications up to 1.7 μm and a two-stage Peltier-cooled...
Avantes BV
Photodiode detector
A Geiger-mode avalanche photodiode detector that can detect ultralow-level light in a variety of applications has been introduced by Hamamatsu Corp. The S10362-11 series multipixel photon counter...
Hamamatsu Corporation
Software development kit
The MultiCore Plus software development kit 1.0 is a suite of software products developed by Mercury Computer Systems Inc. for the Cell Broadband Engine and other multicore processors. Enabling...
Mercury Systems, Inc.
EMCCD cameras
The Cooke Corp. has extended the capability of its sensicam em electron-multiplying (EM) digital 12-bit CCD camera systems and added a new version to the line. The gain settings are calibrated and...
Pulsed lasers
Laseranalytik GmbH’s Lotis-TII series Nd:YAG pulsed lasers and laser systems offer high-stability outputs for wavelengths of 1064 nm and harmonics such as 532, 355, 266 and 213 nm. The lasers...
UHPLC detector
Jasco Inc. has developed a fluorescence detector for ultrahigh pressure liquid chromatography (UHPLC) applications. The XLC-3020FP provides excitation and emission stability over wavelengths from...
Medical laser
Rofin/Baasel Lasertech has enhanced its StarCut Tube, a precision laser cutting system for making medical implants such as stents and other components. The system can cut an 8-mm coronary stent in...
Rofin-Baasel Lasertech
Reflector coating
A technology for coating cold conversion plastic reflectors has been announced by Oerlikon Optics. The Ultem coating is designed for lighting systems used in operating rooms and dentists’...
Oerlikon Optics USA Inc.
High-power LED
The Platinum Dragon LED manufactured by Osram GmbH can withstand twice the output as the Golden Dragon, providing a higher operating current and, therefore, more light. It produces white light at...
OSRAM Opto Semiconductors GmbH
Protein identification
The BioWorks 3.3 advanced protein identification and quantitation software features the Sequest protein search algorithm, which automatically identifies proteins by comparing experimental tandem...
Thermo Electron Corp.
Incubation chamber
A fully enclosed incubation chamber for the PerkinElmer UltraView spinning disk confocal microscope has been launched by Solent Scientific. The chamber system incorporates various research...
Sample processing
Velocity11 has released the Element automated sample processing system with an open platform that provides access to components, enabling rapid reconfiguration of up to nine instruments. The...
Velocity11, Automation Solutions
Microplate handling
Molecular Devices Corp. has introduced the StakMax integrated microplate handling system, which can process up to 50 plates per batch, increasing productivity during experiments. The benchtop...
Molecular Devices, LLC
Photon counter
SUI, a division of Goodrich Corp., has released the SU-02-SPC NIR photon counter. The 19 x 5.25 x 12-in. bench instrument is designed for single-photon counting in the near-IR spectrum from 0.9 to...
Sensors Unlimited - UTC Aerospace Systems
Fiber-coupled laser
Pavilion Integration Corp. has expanded its WhisperIT product line with the addition of a fiber-coupled version of its miniature 532-nm laser module. The green laser is housed in the same compact...
Pavilion Integration Corp.
Multi-purpose microscope
Nikon Instruments Inc. has introduced the AZ100 Multizoom micro/macro imaging microscope for studies of subjects ranging in size from whole animals to single cells. The instrument features a wide...
Nikon Instruments Inc.
Metrology gauges
PI (Physik Instrumente) LP has announced the D-510 family of PISeca capacitive displacement gauges for nanometrology applications. They perform high-precision, noncontact measurements of geometric...
PI (Physik Instrumente) L.P., Piezo Nano Positioning

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