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BioPhotonics: January 2015

Photonics Innovataors Named 2015 Prism Awards Finalists
Finalists include tools for 3-D printing, water analysis and laser-engineered surfaces. Innovative products, inventions and companies will take center stage Feb. 11, as the winners of the 2015...
Justine Murphy, Editor,
Selecting a Microscope Based on Imaging Depth
Optical microscopy has advanced greatly over the past decade. Here’s how to select the right instrument for any particular application. Selecting the right optical microscopy system...
Alec De Grande and Samuel Bonfig, Olympus
Lasers, Optics Enhance Optogenetics Studies
A guide to suitable light sources and fiber optic components for optogenetics research, with a specific emphasis on rodent behavior. The use of lasers and optics for optogenetics is only in...
Niten Olofsson, Iakovos Lazaridis, Konstantinos Meletis and Marie Carlén, Karolinska Institutet, and Ulf Tingström and Håkan Karlsson, Cobolt SE
Line-Narrowed Laser Module Enables Spin-Exchange Optical Pumping
The optical technique enhances MRI technology for diagnosis and other applications. In the past several decades, medical imaging has made huge strides. The field of MRI in particular has seen...
David Irwin and Tobias Koenning, Dilas
Raman Spectroscopy and Microscopy: Solving Outstanding Problems in the Life Sciences
This first article in a two-part series will examine Raman spectroscopy applications in tumor surgery, endoscopy, bacterial identification and more. The second part will cover applications in cell...
Dr. Marinella G. Sandros, University of North Carolina at Greensboro, and Dr. Fran Adar, Horiba Scientific
Microspectroscopy Enables Real-Time Imaging of Singlet Oxygen
A new experimental setup allows researchers to monitor a highly reactive species of molecular oxygen that plays an important role in a wide range of biological processes. Oxygen is one of...
Marek Scholz, Charles University, and Manjul Shah, Princeton Instruments

A Note of Thanks
We’re starting the new year with a note of gratitude to the many contributors who have shared their ideas, results and expertise with BioPhotonics readers. In this and every issue, experts from labs and enterprises around the world keep you updated on the latest technologies and biophotonics applications. If you would like to be one of those contributors this year, please send to my...
Karen A. Newman, Group Publisher,

Laser-Based Imaging Leads to Better Lung Disease Treatment
How sticky is snot? The rest of the world might not ask that question every day, but a group at the University of North Carolina does. They now have an answer, thanks to a laser-based imaging method, and it could enable doctors to monitor and better treat lung diseases. The imaging method uses a combination of nontoxic gold nanoparticles and light to measure the stickiness of mucus that...
Optogenetics Tests Memory Manipulation Theory
Optogenetics is giving scientists a better look at how different parts of the brain can work together to manipulate memories. Using the light-based technique, researchers at the University...
Fluorescent, Magnetic Nanoparticles Aid Bioimaging
Nanoparticles that fluoresce to enable tracking in the body can also be precisely manipulated with magnetic fields. Manipulating the particles with electromagnets is key to using them in...
FRET Offers Real-Time Look at HIV Infection Process
Scientists can now study the motion of HIV proteins on the surface of the virus, opening new possibilities for fighting the disease. A team at Weill Cornell Medical College used...
Blue LED Controls New Diabetes Drug
A new drug for Type 2 diabetes can be controlled with violet-blue light to more effectively release insulin from the pancreas. A team from Imperial College London and Ludwig Maximilian...
Nanoconstructs Aid Ovarian Cancer Targeting
Newly developed nanostructures have proven to be effective vehicles for laser imaging and ablation of ovarian cancer cells. A team from the University of California, Riverside, and the...
Bioimaging Technique Isolates Moving Tissue
Light-guiding technology could take scientists on a journey inside blood vessels. The new technology — time-reversed adapted-perturbation (TRAP) optical focusing, developed by a team...
Photoacoustics Exposes Arterial Plaques
Measuring ultrasound signals generated by a fast-pulsing laser inside an artery could advance diagnosis of cardiovascular disease. A new technique called intravascular photoacoustic imaging...
Microscopy Aids Single-Cell, Whole-Body Imaging
A microscopy and imaging technique could make tissue and potentially whole organisms transparent. A team at the Riken Quantitative Biology Center and the University of Tokyo developed the...
Software Offers Panoramic Views for Endoscopy
Software that fuses together endoscope images could offer a fuller internal view of organs to better diagnose cancer and other ailments. The program — Endorama — developed by...
Handheld Probe Combines Photoacoustics, Ultrasound
A new handheld imaging system that combines photoacoustics and ultrasound produces detailed, real-time images of blood vessels, internal organs and body parts. Researchers from the...
Phosphorescent Bandage Helps Wound Assessment
A “smart” bandage can indicate oxygen concentration in severely damaged tissue, potentially increasing the success rate of surgeries to restore limbs and physical functions. With...
Drugs Enhance SPECT Imaging of Metastatic Cancer
New drugs that bind to metastatic prostate cancer in soft tissue, lymph nodes and bone can enhance SPECT and planar imaging. A new study represents the first time these target-specific...

Iridex Patents Disposable Laser Eye Treatment Device
Iridex Corp. has received a patent for a disposable delivery device for its laser eye-therapy system. The company’s MicroPulse Laser Therapy system is used for the treatment of retina conditions and glaucoma. The new disposable delivery device is planned to be commercially available in the first quarter of 2015. For more information, visit
UC Berkeley Nabs Grant for BRAIN Initiative, Teams with Zeiss
The University of California was awarded a total of $7.2 million in funding from the National Institutes of Health to conduct brain-related research as part of the national BRAIN Initiative. The...
BioLase Revenue Grows, Losses Shrink in Third Quarter
BioLase Inc. reported a net loss of $3.5 million in the third quarter, an improvement over the previous quarter and the third quarter of 2013. Net revenue for this year’s third quarter...

Beautiful things in small packages
Microscopes transport us to another world. They show us the invisible landscapes and vistas of life’s natural processes, normally hidden right under our noses. While it’s not hard to be amazed by the details of our world, some scientists are providing microimaging of the highest caliber – intersecting art with science and beauty with the bizarre – and making people stop in...

Lock-in Amplifier
BNC Scientific, a division of Berkeley Nucleonics, is offering a fast commercial lock-in amplifier produced by Zurich Instruments. The UHFLI (ultrahigh-frequency lock-in amplifier) performs measurements as high as 600 MHz. It extends Zurich Instruments’ scientific support and BNC Scientific’s instruments for high-end research into the fields of quantum and nanophysics, laser...
BNC Scientific
Cell Imaging Software
Ensuring efficient use of time-lapse experiments and microscopy hardware, cellSens imaging software from Olympus is available in version 1.12, providing use of a Graphical Experiment Manager (GEM)...
Olympus Europa SE & Co. KG, Medical Systems & Micro-Imaging Solutions Group
Dual-Mode CCD
A new CCD image sensor from ON Semiconductor can capture 1080p (1920 × 1080) video in scenes with widely varying lighting conditions. The KAE-02150 enables high-dynamic-range imaging...
ON Semiconductor
CMOS Cameras
Basler has released a new series of Ace cameras based on Sony’s IMX174 CMOS sensor. The cameras feature high quantum efficiency, wide dynamic range and extremely low noise, allowing...
Basler AG
Fiber Optic System
The FluoDuoFiber system from art photonics GmbH is a multichannel fiber optic probe for fluorescence sensing of human cells in multiorgan chips (MOCs). The system has four fiber legs (two for...
art photonics GmbH
Atomic Emission Spectrophotometer
New atomic emission spectrophotometers from Shimadzu Scientific Instruments enables detailed chemical, environmental, pharmaceutical, food, metal and electronics analysis. The ICPE-9800 Series...
Shimadzu Scientific Instruments, Inc.
Measuring Microscope
A new optical measuring microscope with image processing capability from Mahr Federal is designed for the measurement and dimensioning of geometric elements. The MarVision QM 300 features a...
Mahr Federal Inc.
Raman Spectroscopy Module
The uRaman-Module flexible Raman spectroscopy system, by TechnoSpex Pte Ltd., can be integrated with imaging systems such as fluorescence microscopes. The module is available with a 532, 633...
TechnoSpex Pte. Ltd.
Optical Balls
Sapphire and ruby balls from Meller Optics Inc. are designed for a range of applications that require precise tolerances, such as medical devices and fiber optic lens systems. They are...
Meller Optics, Inc.
Picosecond Diode Laser
A new pulsed light source from Edinburgh Instruments is optimized for time-correlated single-photon counting (TCSPC). The EPLED 310 diode laser emits at 310 nm, with a typical pulse width of...
Edinburgh Instruments Ltd.
Spectroscopy Software
New software from Horiba Scientific turns the company’s Raman microscopes into high-throughput chemical analyzers, coupling nondestructive analysis with high sample turnaround. The MultiWell...
HORIBA Scientific, HORIBA Scientific
Wearable fNIRS System
TechEn has announced its new wireless functional near-infrared spectroscopy (fNIRS) system. Using low-profile optodes, the device weighs less than 2 lb. It measures brain activation in...
Microscope Add-Ons
Three new add-ons are now available for LaVision BioTec’s TriM Scope II intravital two-photon microscopes. The 4× Cloud Scanner is a beam multiplexer that generates a four-foci...
LaVision BioTec GmbH
Calibration LED
The GL Opti Light LED 127 from GL Optic is an integrating-sphere-based uniform source that offers a comprehensive test system in a compact size. The device uses a patented, multilevel...
GL Optic
Mobile Eye-Tracking System
The Red250 mobile IR eye-tracking system by SensoMotoric Instruments is designed to study neurodegenerative disorders. It features a temporal resolution of 250 Hz, an operating distance of...
SensoMotoric Instruments GmbH
Light-Sheet Microscope
The Zeiss Lightsheet Z.1 microscope system is designed for use with clearing methods to facilitate light-sheet fluorescence imaging. It acquires multiple tiles of Z-stacks with several...
Carl Zeiss Microscopy GmbH, Optical Sensor Systems
Dual-Wavelength Laser
A new laser from Coherent Inc. allows simultaneous, multiwavelength excitation of multiple probes and photoactivation for nonlinear microscopy. The Chameleon Discovery is continuously...
Coherent Inc.

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