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BioPhotonics: November 2011

FEATURES
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To Label – or Not?
Just as research-based studies laid the path for clinical investigations with intravascular OCT and near-infrared reflectance spectroscopy, today’s pioneering research likely will result in a future in which multimodal nonlinear optical imaging will serve as a potent weapon with which to clinically investigate, understand and diagnose a variety of human health factors. Multimodal...
Dr. Neil Anderson, !%Semrock Inc.%!, A Unit of Idex Corp.
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Photocoagulation: Healing Through Laser Damage
Photocoagulation – the deliberate destruction of tissue by absorption of radiant energy and its conversion to heat – is a treatment undertaken to save another area of tissue deemed more...
Marie Freebody, Contributing Editor, marie.freebody@photonics.com
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Diffraction-Imaging Flow Cytometry Enables Rapid Cell Assay
A new method allows fast, label-free cell classification by combining high-contrast image acquisition with automated analysis. This method could open doors for expanded clinical applications such as...
Xin-Hua Hu, East Carolina University and Wavmed Technologies Corp.; Yuanming Fend, Tianjin University; and Jun Qing Lu, East Carolina University
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CSI Experts Find Clues Faster with Microscopy
As criminal cases pile up, automation and digital imaging techniques will help crime scene investigators close them more quickly. Forensic crime shows such as CSI have taken over TV networks...
Marie Freebody, Contributing Editor, marie.freebody@photonics.com
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Inverted Fluorescence Microscopy Aids Microseparation Studies
High-quality video and images from an inverted fluorescence synchronized video microscope show promise for imaging micro- and nanofluidic bioanalyzer prototypes. Researchers working with...
Dr. Yolanda Fintschenko, Labsmith Inc., and Dr. Blanca H. Lapizco-Encinas, Tennessee Technological University


EDITORIAL
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Enhance, Disrupt, Revolutionize, Repeat
In his introduction to a plenary session called “Material Nanoscience, Photonics and Technologies for Revolutionary Innovation” at LIA’s ICALEO (International Congress on Applications of Lasers & Electro-Optics) last month in Orlando, Fla., session chairman Kunihiko Washio of Paradigm Laser Research Ltd. in Tokyo said, “Although incremental innovation within a known...


BIOSCAN
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DNA nanosensors pave way for cancer tests, drugs
Custom DNA molecules can be used to make sensors that can quickly detect a broad class of proteins – and could be used to personalize cancer treatment and even to monitor the quality of stem...
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STED microscopy reveals how immune system attacks infected cells
A new stimulated emission depletion (STED) microscope has yielded unprecedented views of the immune system in action. The superresolution microscope shows how granules from natural killer (NK)...
Ashley N. Paddock, ashley.paddock@photonics.com
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Laser technique produces synthetic tissue for regenerative medicine
Tissue that has been damaged by disease or trauma often cannot repair itself. However, a new picosecond laser technique produces biomimetic matrices that allow the body to regenerate itself using the...
Ashley N. Paddock, ashley.paddock@photonics.com
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Vibrant palette of fluorescent highlighters tracks cells
The palette of fluorescent highlighters used to track the movement of messengers inside single cells has been dramatically expanded to include red and blue fluorescent indicators, which provide...
Ashley N. Paddock, ashley.paddock@photonics.com
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New microscope delves beneath skin to detect cancer
A new type of laser-scanning confocal microscope provides more information than previous versions and holds promise for skin cancer diagnostics. Unlike typical laser-scanning confocal...
Ashley N. Paddock, ashley.paddock@photonics.com
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Sensor enables cheap, portable blood testing
A low-cost, portable technique quickly and reliably detects specific proteins in a sample of human blood, which could benefit a range of medical sensing applications, including diagnosis of cancer...
Ashley N. Paddock, ashley.paddock@photonics.com
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Microscopy, holography team up to reveal neuronal activity
Digital holographic microscopy (DHM) allows observation of neuronal activity in real time and in three dimensions – with up to 50 times greater resolution than ever before – showing...
Ashley N. Paddock, ashley.paddock@photonics.com
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SLIM method measures cell growth
A new imaging technique called spatial light interference microscopy (SLIM) soon may answer the much debated question as to whether cells grow at a constant rate or exponentially. An...
Ashley N. Paddock, ashley.paddock@photonics.com
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Cells open wide for nanothermometers
Nanoscale thermometers have revealed for the first time that individual cells inside the human body register various temperatures and do not adhere to the familiar 98.6 °F norm. For many...
Ashley N. Paddock, ashley.paddock@photonics.com
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Mitosis: New techniques reveal cell division surprise
High-resolution 3-D imaging of a cell’s nucleus undergoing cell division is now possible, thanks to a combination of plunge-freezing and a new method of sample slicing. The findings open up a...
Ashley N. Paddock, ashley.paddock@photonics.com
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Handheld units detect cancer on the go
An inexpensive handheld cancer diagnostic device may soon help physicians in developing nations with limited resources to detect and diagnose the disease and to provide treatment before it’s...
Ashley N. Paddock, ashley.paddock@photonics.com
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Glowing bacteria shed light on what makes biological clocks tick
Scientists have long known that plants and animals are governed by circadian rhythm – a 24-hour cycle of alternating light and darkness to guide biological processes. Although we know that our...
Ashley N. Paddock, ashley.paddock@photonics.com


RAPIDSCAN
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Photonics-related projects score NIH grants
The US National Institutes of Health recently awarded $143.8 million in grants to speed up the translation of research projects into improved health, and several of the recognized projects rely on...
Compiled by BioPhotonics staff
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Avantes BV
Avantes BV, a manufacturer of instruments, light sources, software and accessories for spectroscopic applications, has moved to a state-of-the-art 2700-sq-m facility in Apeldoorn, Netherlands. The...
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Synoptics
Synoptics has established the Advanced Technology Group, a new division within the company that will work with life sciences companies and academic clients to deliver custom imaging equipment to...
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OHSU/FEI Living Lab for Cell Biology
In Oregon, a collaboration between industry and academia has resulted in the creation of a laboratory that will provide researchers with several state-of-the-art electron microscopes to advance the...
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Photonic Solutions
Photonic Solutions of Edinburgh, UK, announced that, with the addition of the Pharos and Orpheus ultrafast laser systems, it has expanded its range of Lithuania-based Light Conversion’s...
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Physik Instrumente (PI) LP
Precision positioning systems manufacturer Physik Instrumente (PI) LP of Karlsruhe, Germany, announced its expansion into the Asian market with the opening of a direct office in Singapore. Before...
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John D. and Catherine T. MacArthur Foundation
The Chicago-based John D. and Catherine T. MacArthur Foundation recently announced 22 new MacArthur fellows for 2011. Recipients of the “Genius Awards” receive $500,000 in...
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GE Healthcare
GE Healthcare of Chalfont St. Giles, UK, is set to dedicate $1 billion of its total R&D budget over the next five years to expanding its advanced cancer diagnostic and molecular imaging...
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Mad City Labs Inc.
Mad City Labs Inc. of Madison, Wis., has opened a direct sales office in Zurich. The company said it established Mad City Labs GmbH to enhance service and support for its European customers and to...
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Palomar Medical Technologies Inc.
Cosmetic laser maker Palomar Medical Technologies Inc. of Burlington, Mass., has announced the receipt of $31 million plus royalties from aesthetic device company Syneron Medical Ltd. of Yokneam,...
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JEOL USA
A supplier of electron microscopes and scientific instrumentation, JEOL USA of Peabody, Mass., and its parent company JEOL Ltd. of Akishima, Japan, have opened JEOL Brasil Instrumentos Cientificos...
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Frankfurt Laser Co.
Laser diode manufacturer and distributor Frankfurt Laser Co. of Friedrichsdorf, Germany, has announced that it will distribute Focuslight Technologies Co. Ltd.’s high-power laser diodes....


POST SCRIPTS
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Genetic approach shows bright promise against AIDS
The immunological battle against AIDS could someday be won in our genes – with a little help from a few glow-in-the-dark cats. A new genome-based immunization strategy from the Mayo Clinic in Rochester, Minn., could help fight feline AIDS and even illuminate ways to combat human diseases, including HIV/AIDS, which has killed more than 30 million people. There is no effective vaccine...
Laura S. Marshall, laura.marshall@photonics.com


PRODUCTS
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Digital Microscope Camera
For live-cell imaging applications, Leica Microsystems has unveiled the DFC365 FX digital microscope camera. To document live cells and rapidly fading fluorescence specimens, it combines high-quality imaging with high temporal resolution for rapid time-lapse recordings. It enables researchers to work efficiently, even with weakly fluorescing specimens. Equipped with a sensitive CCD sensor with...
Leica Microsystems GmbH
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Fiber-Coupled Multibar Modules
Dilas is offering higher-power fiber-coupled multibar laser modules operating at 1940 nm. The high-brightness, high-power modules feature a compact footprint and deliver 30-W output through a...
DILAS Diodenlaser GmbH
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532-nm Laser
Laser Quantum has enhanced its Excel, a continuous-wave 532-nm laser that outputs up to 2 W while maintaining noise at <0.5% rms. Compact and robust in design, its new intelligent smd12 power...
Laser Quantum Inc.
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Polarization Imaging
Bossa Nova Technologies LLC has released a full Stokes polarization imaging camera. Salsa performs live measurement of the full Stokes vector, including the fourth parameter S3, related to circular...
Bossa Nova Technologies
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Fluorescence Illumination
For fluorescence microscopy and live-cell imaging applications, Lumen Dynamics Group Inc. has unveiled the X-Cite XLED1, a high-power LED illumination solution offering advanced triggering...
Lumen Dynamics
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Photomultiplier Tubes
Hamamatsu Corp. has released the H11451 series linear array photomultiplier tube (PMT) modules. The detectors offer high cathode sensitivity, high gain and high-speed response, with fast rise time...
Hamamatsu Corporation
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Laser Platform
Vortran Laser Technology Inc.’s Stradus laser is compatible with µManager open source confocal software that controls confocal microscope systems. The software allows the user to...
Vortran Laser Technology, Inc.
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36-mm Linear Actuator
Haydon Kerk Motion Solutions, a division of Ametek Inc., has unveiled a new version of its 36-mm G4 linear actuator. Included is an adapter plate that allows the smaller 36-mm-outer-diameter unit to...
Haydon Kerk Motion Solutions, Inc.
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Machine Vision Cameras
Imperx Inc. supports a wide range of high-resolution video-capture applications with two 29-megapixel B6620 cameras. High resolution is important for video-capture applications where large areas must...
Imperx, Inc.
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Diode Laser Stacks
Dilas has released high-duty-cycle vertical diode laser stacks that enable long pulse lengths for hair removal and high-energy applications. The compact gold-tin-soldered vertical stacks are designed...
DILAS Diodenlaser GmbH
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CCD Cameras
Princeton Instruments’ PyLoN series controllerless, cryogenically cooled CCD cameras are designed for quantitative spectroscopy applications that demand high sensitivity. The PyLoN:100 and...
Princeton Instruments
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Microstructures
Available from IMT Mask und Teilungen AG are microstructures in sizes down to 0.150 µm in combination with optical coatings on glass and other substrates. They are customized for original...
IMT Masken und Teilungen AG
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Ceramic Motor Stage
Nanomotion has added a Z-wedge vertical stage to its FB range of compact nanometer-level micropositioning mechanics. The stages complement a modular and compact range of linear, rotary and...
Nanomotion Inc.
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GHz Photoreceiver
New Focus, a Newport Corp. brand, introduces the GHz Nirvana, a high-speed photoreceiver with automatic signal balancing. It offers high bandwidth and fiber coupling. The autobalance feature...
New Focus
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Compact Focus Module
New Scale Technologies Inc. has upgraded the lifetime specification of its miniature M3-F focus module and provided new repeatability data for it. The module replaces fixed lens holders in compact...
New Scale Technologies, Inc.
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EMCCD Microscopy Camera
For high-sensitivity low-light imaging, QImaging has released the Rolera Thunder electron-multiplying CCD (EMCCD) microscopy camera. Its quantitative capability with linear EM gain and high frame...
QImaging
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Infrared AR Coatings
Proteus, Artemis Optical Ltd.’s high-durability infrared antireflection (AR) coatings, deliver high transmission over a specified waveband that increases the system’s signal-to-noise...
Artemis Optical Ltd.
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High-Speed Cameras
Vision Research, a business unit of the Materials Analysis Div. of Ametek Inc., has introduced the Phantom v1210 and v1610 1-megapixel digital high-speed cameras, which feature high-definition and...
Vision Research Inc., Phantom Digital High-Speed Cameras
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Laser Alignment Tuning Kits
Newport Corp. has released its LAKIT series laser power alignment tuning kits. Suitable for use in research setups, the kits include the new 1917-R laser power meter and a wide selection of optical...
Newport Corporation
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Automated Work Cell
Nordson Asymtek has introduced an automated work cell for film-frame wafer-level packaging applications. Intended for customers who want to buy their dispensing and handling equipment from a single...
Nordson Asymtek
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Laser Diode Drivers
The PPS series analog laser diode drivers/controllers manufactured by Portable Power Systems Inc. can operate in pulsed or continuous-wave mode. Depending upon the unit, voltages range from 0 to 250...
Portable Power Systems, Inc.

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