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Autoflex III Mass Spectrometer

Photonics.com
Aug 2006
Bruker Daltonics Inc.Request Info
 
PRAGUE, Czech Republic, Aug. 28, 2006 -- Bruker Daltonics introduced its new autoflex III smartbeam vertical MALDI-TOF (matrix-assisted laser desorption-ionization/time-of-flight), or TOF/TOF, mass spectrometer at the 17th International Mass Spectrometry Conference, being held this week in Prague. Bruker said that mass resolution, accuracy, sensitivity, analytical versatility and reliability have been enhanced in the new autoflex III smartbeam instruments for optimum performance in expression proteomics and quantitative proteomics, as well as in peptide/protein biomarker discovery, identification and validation.

autoflex.jpgBased on Bruker Daltonics' smartbeam laser technology, the novel autoflex III series is particularly suited for MALDI molecular imaging applications in in-vitro imaging of peptide and protein biomarker distributions in tissue sections, e.g., in tumor regions. The smartbeam laser allows variable repetition rates from 1 Hz up to 200 Hz, with a computer-controlled, adjustable laser focus size and unrivaled spatial resolution, Bruker said.

In addition to a fourfold sensitivity increase compared to the autoflex II, the latest autoflex III offers major advances in mass resolution over a broad mass range, using panoramic PAN technology -- the same technology used in Bruker Daltonics' top-of-the-line ultraflex TOF/TOF series. Mass spectra with the simultaneous highest resolution over an extended mass range greatly increase success rates in protein database identifications, without the need to optimize instrument parameters.

Bruker Daltonics said with LIFT TOF/TOF ion optics and unique smartbeam technology for unprecedented analytical versatility in sample types, matrices, etc., the autoflex III and ultimate-performance ultraflex III are the preferred MALDI systems for quantitative expression proteomics, top-down proteomics, intact protein analysis, LC-MALDI workflows and clinical proteomics.

The new autoflex III is fully integrated into Bruker Daltonics solution packages such as its ClinProt for biomarker discovery, MALDI molecular imager for biomarker distribution in tissue section, its Proteineer line (the 2-D gel-based proteomics suite) and its Proteineer LC line (the LC-based proteomics suite).

Michael Schubert, executive vice president of Bruker Daltonics, said, "We have now implemented many of the cutting-edge technologies from our top-of-the-line ultraflex MALDI-TOF/TOF, like smartbeam laser, PAN resolution over a broad mass range and 4X sensitivity enhancements, into our compact vertical autoflex III system to perform at the highest level. Moreover, statistical biomarker data obtained with the autoflex III can now be merged easily with molecular images for in-depth investigation of the spatial distribution of peptides and proteins in tissues."

For more information, visit: www.imsc2006.org or www.bdal.com; e-mail: ms-sales@bdal.com

Bruker Daltonics Inc.
40 Manning Rd.
Manning Park
Billerica, MA 01821
Phone: (978) 663-3660
Fax: (978) 667-5993


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GLOSSARY
mass spectrometer
A device used to measure the masses and relative concentrations of atoms and molecules. It utilizes the Lorentz force generated by external magnetic field on a moving charged particle, in which the particles are deflected by the magnetic field according to their masses. Once deflected, the particles are detected and recorded electrically to provide a mass spectrum of the input beam of ions. 
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