The PhotoFluor, a high-output light source for fluorescence microscopy, is available from Chroma Technology Corp. The device combines a metal halide lamp with a sputtered heat-blocking optic to deliver light across the range of 340 to 650 nm. It allows bright imaging of DAPI, Hoechst and other UV-absorbing fluorochromes. The lamp lasts ∼2000 h and exhibits a minimal decrease in output over time. It comes with a five-position discrete neutral density wheel and an easy-to-use display and user interface.