Request InfoFor Live-Cell ResearchLeica Microsystems GmbHWETZLAR, Germany, Oct. 25, 2007 -- The new Leica TIRF (total internal reflection fluorescence) microscope system, called the Leica AM TIRF MC, allows the entire fluorescence excitation spectrum to now be used for real-time visualization of live cell dynamics, according to manufacturer Leica Microsystems GmbH. Leica's scanner sensor automatically matches the TIRF angle at all wavelengths to the required penetration depth, and positions the laser so that the TIRF penetration depth remains constant even when the wavelength is changed. Researchers using Leica's TIRF technology benefit from a unique level of convenience as well...See full productRelated content from Photonics MediaPRODUCTSPromoted Content May 2022 IssueNew Wavelengths: 473 nm, 607 nm, 698 nmOxxius’ LaserBoxx family of DPSS laser / laser diode modules offers new wavelengths not readily available to the market: 473 nm (SLM) @ 50 mW, 607 nm @ 200 mW, and 698 nm @ 100 mW. This family...Promoted Content May 2023 IssueLasers and Component SpectrometersMetrohm has opened a new webshop for lasers, component spectrometers, and Raman spectroscopy sampling solutions. The new m-oem brand includes four Metrohm companies: Innovative Photonic Solutions...BioPhotonics Jan/Feb 2024 IssueLaser Scanning MicroscopesEvident’s FLUOVIEW™ FV4000 confocal laser scanning microscope and FV4000MPE multiphoton laser scanning microscope, feature advancements in imaging technology that empower researchers to...Promoted Content September 2022 IssueWe Make Your Laser for Medical ApplicationsThe FISBA READYBeam™ is our answer to customers' increasing demand for a compact, powerful, and reliable multicolor laser source that can be easily integrated into existing set-ups. The...ARTICLESPhotonics.com 4/20/2022Rotating Laser Enables Faster, Longer Imaging of CellsA microscopy method developed at the University of Freiburg is able to resolve cellular-level detail without fluorescence, enabling observations 100 to 1000× longer and 10 to 100× times...BioPhotonics Jul/Aug 2022 IssueLaser Endomicroscopy Enables Real-time Detection of Lung CancerResearchers at the Abramson Cancer Center at the University of Pennsylvania have developed a method to detect lung cancer at the cellular level in real time during biopsy. The method ensures earlier...BioPhotonics Sep/Oct 2022 IssueHigh-Throughput Imaging Links Microbial Metabolism With Cell IdentityAn imaging platform for investigating microbiomes in medical and environmental samples can perform high-throughput metabolism and identity analyses with single-cell resolution. Called SRS-FISH, or...BioPhotonics Jul/Aug 2023 IssueCell Manipulation Technique Enters into Commercial MarketIn cell biology and medical imaging, the targeted manipulation of cells under controlled conditions is a major challenge in understanding processes and causal relationships. Researchers are dependent...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookInfrared Spectral Selection: It Begins with the DetectorSpectral selection is a powerful tool that enhances conventional imaging tremendously. Most imaging systems, including the human eye, are designed to image light over a broad range of the spectrum....Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best ApproachThe term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookCamera Resolution: Combining Detector and Optics PerformanceCamera resolution depends upon the optical blur diameter and the detector size. Schade combined these to create an equivalent resolution that is a function of Fλ/d where F is the focal ratio,...Photonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...WHITEPAPERSPhotonics.com 4/20/2023Is a DIY Microscope for You?For some advanced microscopy and nanoscopy techniques it becomes necessary to modify existing instrumentation or build an instrument from scratch. This article helps readers determine whether a...Photonics.com 10/13/2023Unveiling Insights: Remote Sensing Mapping Laser SolutionsExplore Lumispot Tech's advanced remote sensing mapping laser solutions, enhancing geospatial technology and insights. Delve into our capabilities in satellite imagery, aerial mapping, and spatial...Photonics.com 2/16/2024Rapid Automated Modular MicroscopeOverview of Rapid Automated Modular Microscope.Photonics.com 2/16/2024FTP-2000 Focusing Translation PlatformOverview of FTP-2000.WEBINARSPhotonics.com 6/11/2015Biophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...Photonics.com 10/26/2023Streamlined Single-Molecule FRET and FCS Measurements for Structural Biology and Phase Separation StudiesQuantitative single-molecule and time-resolved fluorescence techniques offer new insights into many samples from various research areas such as dynamic structural biology; cellular mechanisms driven...Photonics.com 3/21/2013Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 10/24/2023Vibrational Photothermal Microscopy Provides a Picture of Life in Live CellsRecently developed mid-infrared photothermal (MIP) microscopy opens a new window to look at molecules inside a living cell. In MIP microscopy, a visible beam is used to probe the local change of...PHOTONICS DICTIONARY+ TERMSPhotonics DictionarySTED microscopySTED microscopy, or stimulated emission depletion microscopy, is a superresolution imaging technique in fluorescence microscopy that surpasses the diffraction limit, enabling the visualization of...Photonics Dictionarytwo-photon fluorescenceThis results from the simultaneous absorption of two photons, each having half the energy needed for excitation and requiring a high spatial and temporal concentration of photons. The ensuing...Photonics Dictionarytotal internal reflection fluorescenceTotal internal reflection fluorescence (TIRF) microscopy is an advanced fluorescence microscopy technique that leverages the principle of total internal reflection to selectively illuminate and image...Photonics Dictionaryspectral flow cytometrySpectral flow cytometry is an advanced flow cytometry technique that expands the capabilities of traditional flow cytometry by utilizing spectral information from fluorochromes to enhance...VIDEOSPhotonics.com 11/20/2023Andor Scientific SolutionsAccelerate your research with the world's most sensitive cameras. Our market-leading portfolio includes sCMOS, EMCCD, CCD, and ICCD technologies, with broad application coverage for life and physical...Photonics.com 2/21/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 3/27/2013Mobile 3-D, Spin Hall Effect & EMCCD - LIGHT MATTERS 03.27.2013-Mobile 3-D -Spin Hall Effect -EMCCD On this week’s show, glasses-free 3-D goes mobile, the strongest signal yet of the photonic spin Hall effect is obtained by a metamaterial, new theory suggests an...Photonics.com 11/20/2023Andor's Life Science Research SolutionsAt Andor, it matters to us that the products we develop make a real difference to our customers and contribute significantly to their research across Immunology, Microbiology, Neuroscience, Cells &...PHOTONICS BUYERS' GUIDE CATEGORIESFluorescence MicroscopesSlow Scan CamerasCCD Image SensorsA CCD image sensor is a type of electronic device used to convert optical images into electronic signals. It consists of an array of light-sensitive pixels, each capable of converting photons (light)...Research MicroscopesCOMPANIESPhotonics Buyers' GuideAndor TechnologyAndor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded...Photonics Buyers' GuideOZ Optics LimitedEstablished in 1985, OZ Optics is a leading worldwide supplier of fiber optic components, test equipment and sensors. OZ Optics manufactures its products in three locations, Ottawa (Canada),...Photonics Buyers' GuideExcelitas Technologies Corp.Excelitas Technologies® Corp. is a leading industrial technology manufacturer focused on delivering innovative, market-driven photonic solutions to meet the illumination, optical, optronic,...Photonics Buyers' GuideEdinburgh Instruments Ltd.Founded in 1971, Edinburgh Instruments Ltd. is a global provider of sophisticated, state-of-the-art analytical instrumentation for optical spectroscopy. We design and manufacture a range of...