Featuring improved femtosecond multiphoton technology, the LSM 710 NLO laser scanning microscope from Carl Zeiss MicroImaging Inc. is suitable for basic and biomedical research applications. Offering a high signal-to-noise ratio, it acquires high-resolution images of fluorescent structures in living animals and in thick tissue specimens, enables long-term observation of development processes, and provides functional imaging in combination with the photomanipulation of fluorescent structures. The system can record up to five fluorescence signals simultaneously in the nondescanned mode. Its GaAsP nondescanned detector and signal decoupling directly on the objective lens result in higher sensitivity. The scanning module transmits over the entire wavelength range up to 1100 nm.