MatriCal Inc. has introduced the patent-pending Squirt benchtop multiformat microplate washer. In contrast with conventional plate washers that rely on multiple clog-prone nozzles, the instrument employs a slit manifold that accommodates high salt concentration buffers and detergent wash solutions. It achieves dilution efficiency greater than 106, facilitates switching between SBS/ANSI plate formats, and eliminates manual wash manifold and machine adjustments. Variable wash angle, dispense speed and pressure settings allow for optimizing cell-based and ELISA assays, with wash times under 10 s in all formats. Inter- and intraplate washing efficiency eliminates a source of unexpected cell death or lack of signal strength.