MatriCal Inc. has introduced low-volume 384 and 1536 clear-bottom MatriPlates designed to reduce tissue culture demands by seeding as few as 500 cells per well. Working volumes for the 384 plates are 40 and 70 μl in half height (10.4 mm) and standard height (14.35 mm) formats, respectively. For the 1536 plates, the working volumes are 6 and 10 μl, respectively, for the half and standard heights. They have a flatness of ±50 μm, and they allow fast read times and are scratch-resistant. Viewing options include 0.72-mm-thick glass, 0.17-mm coverslip glass, UV-transparent quartz and bottomless. Applications include fluorescence correlation spectroscopy, nephelometry and cell-based assays for scanning and confocal microscopes.