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TCS SMD

Photonics.com
Aug 2009
Leica Microsystems GmbHRequest Info
 
Single-Molecule Detection System
WETZLAR, Germany, Aug. 31, 2009 – A single platform to study the dynamics of cellular processes has been launched by Leica Microsystems GmbH. The TCS SMD series is a single-molecule detection system that offers an integrated platform for the most common single-molecule techniques, such as fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy.

It enables performance of the newer and more precise verification methods for molecule concentrations and interactions: fluorescence cross-correlation spectroscopy and fluorescence lifetime correlation spectroscopy.

Leica_TCS-SMD.jpgThe system integrates hardware and software from PicoQuant with the high-end Leica TCS SP5 II confocal microscope. Researchers now can control a complete single-molecule detection experiment via one interface, the proprietary LAS AF software. The coordination of different hardware and software components for one single-molecule detection experiment is now a thing of the past.

Complex single-molecule detection technologies are no longer complicated because of the user-friendly design of the system. Quick and easy operation is ensured by dedicated application wizards that guide the user step-by-step through experiments and maximize the reproducibility of data. With the universal single-molecule detection raw data format, the same data file can be analyzed in various ways, leading to quantification with maximum content.

For more information, visit: www.leica-microsystems.com  

Leica Microsystems GmbH 
Ernst-Leitz-StraBe 17-37 
D-35578 Wetzlar
Germany
Phone: +49 64 41 29-40 00
Fax: +49 64 41 29-41 55


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GLOSSARY
fluorescence correlation spectroscopy
A powerful method, referred to as FCS, for determining the average diffusion coefficients of fluorescent molecules in solution or membranes. FCS measurements rely on recording the transition of several thousands of molecules through the focal volume. The combination of short measurement times along with free positioning or scanning of the observation spot makes FCS an excellent tool for investigating diffusion heterogeneity over time and space.
photonics
The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
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