Request InfoLeica Microsystems Inc.The TCS SP5 confocal microscopy system from Leica Microsystems Inc. has been enhanced with the company’s application suite for advanced fluorescence, supporting the need in life sciences research to extract meaningful, reproducible data from experiments on confocal systems. The software provides wizards for molecular distance and interaction analysis, fluorescence recovery after photobleaching and fluorescence resonance energy transfer acceptor bleaching and sensitized emission. Its live-data mode enables interactive physiological analysis with flexible sequencing of experiments and online...See full productRelated content from Photonics MediaPRODUCTSPromoted Content February 2024 IssueOEM-Ready Microscope SubsystemsThe Nucleus™ microscopy platform provides a complete set of interchangeable hardware modules and software tools, making it ideal for OEMs and lab managers engaged in fluorescence cellular...Promoted Content April 2024 IssueGet More Data: Automate Your MicroscopeZaber offers a selection of standard and customized motorized microscope stage products. They offer: Exceptional Performance Maximize your throughput and consistency with up to 500-nm...Promoted Content November 2023 IssueNucleus™ Automated MicroscopesThe Nucleus™ microscopy platform provides a complete set of interchangeable hardware modules and software tools, making it ideal for OEMs and lab managers engaged in fluorescence cellular...Promoted Content March 2024 IssueUltra-Precision Microscopy DemoThe Nucleus™ microscopy platform provides a complete set of interchangeable hardware modules and software tools, making it ideal for OEMs and lab managers engaged in fluorescence cellular...ARTICLESBioPhotonics.com April 2024 IssueMicroprism-Mediated Calcium Imaging Reveals Neural Dynamics Over TimeAn approach to deep brain imaging developed at the University of Washington uses microprisms to provide stable tracking of neuronal activity over a large field of view. According to the research...BioPhotonics Jan/Feb 2023 IssueNobel Prize-Winning Techniques Help Resolve Imaging ChallengeUsing a technique that was recently awarded the 2022 Nobel Prize in chemistry, researchers at Cornell University used expansion microscopy to study lipids, the water-repellent, dynamic components...Photonics.com 5/5/2022Internal Reflection-Based Microscopy Images Single ProteinA team from Arizona State University (ASU) has introduced evanescent scattering microscopy (ESM), a label-free method for sensitive imaging of biomolecules, including proteins. The single-molecule...Photonics.com 2/23/2024SPAD Elevates Spatiotemporal Resolution in Conventional MicroscopesImage scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides signal-to-noise ratio (SNR), optical sectioning, and spatial...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookFluorescence Lifetime Imaging: Choosing the Best ApproachThe term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookDetectors: Guideposts on the Road to SelectionAny number of medical, industrial, and analytical applications requires the detection of light. Chemiluminescence, bioluminescence, fluorescence, and atomic absorption are just a few, and all require...Photonics HandbookLasers for Microscopy: Major TrendsLaser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light SourcesAs recently as five years ago, shopping for a microscope light source was fairly straightforward. For routine applications, it was tungsten halogen, typically 100 W, while for fluorescence, it was an...WHITEPAPERSPhotonics.com 4/20/2023Is a DIY Microscope for You?For some advanced microscopy and nanoscopy techniques it becomes necessary to modify existing instrumentation or build an instrument from scratch. This article helps readers determine whether a...Photonics.com 2/28/2024Multi-Bandpass Filters for FluorescenceLearn how multi-bandpass filters combined with multiple LEDs can enable versatile and compact fluorescence instrumentation.Photonics.com 1/10/2024Spectral, Spatial and Temporal Optimization of Solid-State Light Engine OutputSpecifications for illumination systems for biomedical imaging and industrial metrology generally converge on spectral, spatial and temporal light output characteristics. This article describes some...Photonics.com 1/10/2024Laser Light Engine Output StabilityIn this white paper, Dr. Iain Johnson, Lumencor’s Director of Technical Support, tests Lumencor’s laser-based CELESTA Light Engine for consistency, power, and stability using continuous wave...WEBINARSPhotonics.com 10/26/2021High-End Optical Filters: Challenges and Solutions to Optimizing Fluorescence AnalysisAdvanced optical thin-film coating technology is instrumental for the manufacturing of filters, mirrors, or beamsplitters with superior optical characteristics. Monitored control of the coating...Photonics.com 10/27/2022KEYNOTE: Raman Spectroscopy Provides Vital Analysis for Biomedical Research and Clinical DiagnosticsEspecially in the fields of the life sciences and medicine, Raman-based technologies have proven their great potential, and they increasingly complement established methods such as fluorescence...Photonics.com 10/27/2022KEYNOTE: Specialized Laser Probes Capture Fluorescence Detail and Drive DiagnosticsArrigoni discusses the various applications of lasers to biology and medicine, and categorizes them by the type of process involved and the most significant trends: Fluorescence (spectral) imaging by...Photonics.com 6/2/2022Advances in LED Illumination for Fluorescence ImagingLED illumination for fluorescence microscopy systems has progressed significantly from a time when LED sources had low optical power and a limited range of wavelengths. While the benefits of LED...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionarywide-field fluorescence microscopyWide-field fluorescence microscopy uses either naturally occurring structures or staining with fluorescent tags that are activated by specific wavelengths of light and then emits a different...Photonics DictionaryphotobleachingPhotobleaching is a phenomenon in which the fluorescence of a fluorophore (a fluorescent molecule or dye) is permanently reduced or eliminated upon prolonged exposure to light. This process occurs...Photonics Dictionarycalcium indicatorA calcium indicator is a molecule that is sensitive to changes in calcium ion (Ca2+) concentrations in biological systems. These indicators are commonly used in various fields, including cell...Photonics DictionarymicroscopyMicroscopy is a scientific technique that involves the use of microscopes to observe and study objects that are too small to be seen with the naked eye. Microscopes are instruments that magnify and...VIDEOSPhotonics.com 5/2/2022Applied Scientific InstrumentationEstablished in 1990, Applied Scientific Instrumentation is a reknown American company committed to the advancement of science. ASI products have been thoroughly tested and evaluated in numerous labs...Photonics.com 1/9/2024CELESTA Light Engine - Customer Success StorySolving MERFISH challenges for Spatial TranscriptomicsPhotonics.com 11/20/2023New Dragonfly 600 Confocal Microscope System - Andor TechnologyThe Dragonfly 600 confocal microscope system delivers outstanding multi-dimensional images from subcellular (nm) to whole organism (cm), while significantly boosting productivity. Its unrivalled...Photonics.com 11/20/2023New ZL41 Cell & Sona sCMOS - Easy, Flexible, Cost-Effective Super Resolution Microscopy - Andor TechnologyEasy and Cost-Effective Super-Resolution to ~100 nm. Andor has introduced two new highly innovative sCMOS cameras, both delivering easy and cost-effective access to super-resolution capabilities and...PHOTONICS BUYERS' GUIDE CATEGORIESFluorescence MicroscopesSpectrofluorometersA spectrofluorometer is an automatic scanning instrument that is used to study a substance's fluorescence over a wide range of wavelengths. It consists of a radiation source, a grating that functions...Fluorescent Light SourcesA fluorescent light source is a tube containing mercury vapor and lined with a phosphor. When current is passed through the vapor the strong ultraviolet emission excites the phosphor, which emits...Velocimetry Laser SystemsCOMPANIESPhotonics Buyers' GuideMad City Labs Inc.Mad City Labs, Inc. is a leading manufacturer of piezo nanopositioning systems and instrumentation capable of sub-nanometer positioning resolution. Our product line of nanopositioners,...Photonics Buyers' GuideAvantier Inc.Avantier Inc. is an unparalleled leader in providing innovative imaging systems solutions and optical systems solutions. We offer advance precision custom optical design, optical engineering...Photonics Buyers' GuideAvantes BVAvantes has spent the last 30 years refining its mission as a trusted and innovative optical instruments and solutions source. Focused on applications and measurements, Avantes offers Spectrometers,...Photonics Buyers' GuideEdinburgh Instruments Ltd.Founded in 1971, Edinburgh Instruments Ltd. is a global provider of sophisticated, state-of-the-art analytical instrumentation for optical spectroscopy. We design and manufacture a range of...