The Orca-D2, a high-sensitivity camera for simultaneous dual-wavelength imaging, is available from Hamamatsu Photonics UK Ltd. Featuring two CCD devices and interchangeable optical blocks, the camera delivers ease of use with optical setup steps, including image alignment and focusing. It provides a wide field of view during wavelength imaging and delivers high sensitivity, low noise and a wide dynamic range. Its proprietary vacuum-sealed chamber technology promotes long-term, maintenance-free operation for demanding applications. It is suitable for Förster resonance energy transfer, ratio imaging and dual-wavelength total internal reflection fluorescence.