Wyatt Technology Corp. has launched the Möbiuζ instrument for fast, reliable and noninvasive measurements of macromolecular electrophoretic mobilities. The laser-based device provides reproducible measurements of mobilities of liposomes, viruslike particles and protein samples, including antibody formulations, bovine serum albumin (BSA) and lysozyme. Through parallelism of detection, it measures in <1 min, provides sufficient data to average away molecular diffusion and extends the measurable molecular size range below 2 nm. The reduced measurement time preserves fragile protein samples. Detection sensitivity is 2 mg/ml for lysozyme and 0.5 mg/ml for BSA. Simultaneous measurement of the macromolecular hydrodynamic radius is available with the WyattQELS (quasielastic light scattering) option, which uses backward scattered light to determine the sample translational diffusion coefficient.