Bruker Daltonics has announced two updated software versions, ClinProTools 2.1 and flexImaging 2.0. When integrated, the packages allow researchers to merge statistical analysis on Maldi-Tof profiling spectra with molecular images of peptide and protein biomarker tissue distributions. The systems facilitate biomarker discovery and validation from large sample cohorts, and the application of the same statistical analysis methods to differentiate between areas on tissue sections. The programs’ capabilities enable clinical research on typing of tissue samples and subtyping of tumor types. For use with supervised and unsupervised approaches, ClinProTools 2.1 includes preanalytical effects, such as sample drawing, storage and preparation. Data sets originating from one sample class can be tested for unexpected variations before application in any comparisons with other sample classes. A receiver operating curve plots the separating power of all individual signals to discriminate between the sample classes.