The Mipos 100 PL is an enhanced piezoelectric objective lens-positioning system from piezosystem jena GmbH. Applicable in standard and in inverse microscopy, the PL replaces the “upside-down” Mipos 100 UD version for inverse microscopy applications. The model offers motion of up to 100 μm and 140 μm in closed- and open-loop modes, respectively. The PL version is compatible with objectives of up to 40 mm in diameter. It is available with an integrated measurement system, either strain gauge or capacitive sensor.