MassWorks is an easy-to-use postdata-acquisition software package from Cerno Bioscience. Combining proprietary MSIntegrity calibration technology and mathematical algorithms, the program improves mass accuracy by up to a hundredfold. Suitable for pharmaceutical and biotechnology mass spectrometry applications, it uses DirectRead technology to read most instrument data formats without importing or exporting to a clipboard and without requiring intermediate data-exchange formats. Fast and versatile, the software helps achieve high mass accuracy with instruments that have unit mass resolution, and it helps improve the results from high-resolution devices. It includes a calibration wizard to guide users through the selection and processing of standard ions.