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  • More Automated Microscope
Nov 2010

VICTOR, N.Y., Nov. 10, 2010 — An automated microscope for use in the life sciences has been released by Till Photonics. The state-of-the-art More is a multipurpose light microscopy platform for high-end applications and is designed for experiments with living cells.

The real-time protocol engine allows for high 3-D acquisition speed and optical sectioning with minimized photobleaching. The integrated design enables millisecond switching between different applications like Förster resonance energy transfer, fluorescence recovery after photobleaching, total internal reflection fluorescence, structured illumination at up to 10 fps and wide-field fluorescence.

Sophisticated acquisition software provides automated experiment control of all motorized modules and real-time online analysis.

Features include fast motorized modules, high-precision voice coil technology for high-speed, a Z-drive, precise relocation, thermal stability and low temperature drift that enables optimized image acquisition. Live acquisition software executes real-time experiment protocols with optimized timing and synchronization for high speed with minimal bleaching. Quiet frame technology eliminates internal vibrations and structure-borne sound.

The platform concept enables multicolor epifluorescence and transmission experiments.

Focus drift is typically <0.1 mm/h.

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An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
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