HAMBURG, Germany, April 20, 2011 — Olympus Europa Holding GmbH has released the inverted IX81, a microscope with a ZDC2 Z-Drift compensation system. The instrument provides sharp images and ensures that samples are always in focus. Two modes, continuous and one-shot, enable completion of time-lapse experiments. The Z-Drift compensation system continually monitors the distance between the objective lens and the sample surface, maintaining accurate focus during even the fastest time-lapse experiments. It automatically maintains focus when capturing multiple images. The one-shot mode facilitates applications requiring multiple focal positions. Providing high speed, accuracy and flexibility, the microscope system is suitable for live-cell imaging, maintaining optimal focus image after image, regardless of experiment length or complexity. The microscope is stable, rigid and reliable. Proprietary UIS2 objectives provide high contrast, brightness and resolution. It combines seamlessly with the ZDC2 Z-Drift compensation module to provide automatic focal adjustment. The ZDC2 uses an infrared laser diode to locate the interface between the slide coverslip and the surrounding media. Because the relationship between the sample and the coverslip tends to be consistent, the microscope system remains focused in response to external factors, via rapid adjustment of the nosepiece. Adjustments made using the ZDC2 are fast and accurate. The continuous mode of the ZDC2 system provides real-time control of focal accuracy, maintaining it even during rapid capture experiments. This new mode also is suitable for more complex applications, such as total internal reflection microscopy. For longer time-lapse studies, the one-shot mode can be employed, maintaining accurate focus for hours, days or weeks at a time. It also allows users to image multiple sample wells — for example, those found in tissue culture plates — independently adjusting focus to provide clear images from every well. The complete system is compatible with a range of proprietary hardware and software, including cellSens Dimension and xcellence, and it integrates fully with environmentally isolated stage incubation systems.