The cell imaging and analysis instrument Cell Metric from Solentim Ltd. is engineered to provide a high-throughput work flow solution to screen for colonies from single-cell cloning experiments. It uses proprietary non-image-based focusing to locate all possible colonies by imaging the whole well, right up to the edge. The platform provides complete and accurate measurement of cells without removing them from the culture plate, and without addition of stains or dyes. This ensures that cells are suitable for use in downstream experiments. The system can identify every healthy, viable cell clone from large multiwell screening projects and can track the visual history of the colonies back to single cells. Its imaging technology overcomes the problems of shadowing and edge effects.