Hamamatsu Photonics has introduced the ORCA-Flash4.0 scientific CMOS camera. Featuring good quantum efficiency, low noise, high resolution and fast readout, it delivers better signal-to-noise characteristics than electron-multiplying CCDs, cooled CCDs and first-generation scientific CMOS cameras, the company says. Its high sensitivity means that one camera can accommodate a variety of imaging needs, including superresolution microscopy, total internal reflection fluorescence microscopy, live-cell green fluorescent protein imaging and high-speed calcium ion imaging. The camera offers quantum efficiency values of >70% at 600 nm and 50% at 750 nm, and it produces only 1.3 e— of read noise at 100 full-resolution frames per second. The combination of high quantum efficiency and low noise, in the absence of electron-multiplying CCD multiplicative noise, means that images are no longer limited by the camera.