MELVILLE, N.Y., Jan. 1, 2013 — A high-content microscope featuring speed and flexibility for imaging and managing biological assays using a system based on the Nikon Ti inverted microscope and NIS Elements HC software has been unveiled by Nikon Instruments Inc. The system provides a dedicated interface for high-content acquisition and analysis routines, built on an integrated database for seamless data management and processing. It incorporates the functionality of the Ti+ Perfect Focus microscope with interchangeable options for high-speed piezo-based autofocusing, plate handling, solid-state light source and fast wavelength switching as well as NIS-Elements camera model support. Magnification and fluorescence filters are exchangeable. Features include streamlined high-speed automated well plate acquisition, data review analysis and management of multiple well plate runs; easy step-through plate configuration navigation; a library of commonly used well plate formats; an easy routine for labeling wells and their treatments; automated alerts through text and email for system updates; automatic scheduling for managing the experimental pipeline; and real-time viewing of data acquisition and analysis progress for instant inspection and evaluation. The system displays high-content data in a variety of viewing options and formats to enable full access to metadata, customizable heat maps, measurement results, generated binary masks, assay results and sample labeling. Data is easy to filter and export.