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  • OpenPlex Research Platform
Jul 2013
HORIBA ScientificRequest Info
EDISON, N.J., July 30, 2013 — OpenPlex, Horiba Scientific’s redesigned manual label-free SPRi-Lab+ system, uses surface plasmon resonance imaging (SPRi) for real-time analysis of label-free molecular interactions in a multiplex format.

The research platform offers the advantages of conventional SPR systems but can measure hundreds of interactions in a single experiment. It also can give qualitative and quantitative information of the interactions, such as concentration, affinity, and association and dissociation rates. Molecular interactions involving proteins, DNA, RNA, oligosaccharides, living cells, polymers or nanoparticles can be characterized and quantified.

The new configuration enables simultaneous fluorescence and electrochemistry experiments to be performed, and its optical window design enables fluorescence information to be gathered either from the ensemble of experiments or individually with a microscope. An open “cuvette” configuration allows for OpenPlex to monitor electrochemical deposition of materials.

The system is compatible with Maldi-ToF mass spec analysis, enabling secondary identification of species for “ligand fishing” experiments. In situ trypsin digestion Maldi provides protein mass fingerprinting.


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