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Optogenetics Microscopy

Siskiyou Corp.Request Info
Optogenetics Microscopy from SiskiyouThe Siskiyou IS-OGP is a simple, turnkey, modular solution (patent pending) for integrating an external laser beam into an existing microscope in optogenetics experiments that utilize a laser spot to stimulate target neurons. Specifically, the IS OGP provides a means to introduce a fiber-coupled laser beam into the infinity space of leading optical microscopes having a trinocular setup (including those from Nikon, Olympus, and Zeiss), and then to position the focused laser stimulation spot (10 µm typical with 20X objective) with sub-micron accuracy, anywhere within the field of view.


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An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of cells...
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