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Microscopy Cage

Photonics.com
Apr 2016
Neurotar Ltd.Request Info
 
HELSINKI, April 14, 2016 — Microscopy CageNeurotar Oy’s Mobile HomeCage is an accessory device for microscopy and electrophysiology, enabling high-precision tests in the brain of awake, head-fixed, but otherwise freely moving rodents. It allows neurophysiological techniques such as in vivo two-photon microscopy, optogenetics, intrinsic optical imaging and in vivo patch-clamp to be combined with behavioral paradigms in a single experiment.

The device integrates Prior Scientific’s Z-Deck, an ultrastable, height-adjustable platform designed specifically for electrophysiology and microscopy applications in neuroscience and available with an integral motorized positioning stage, a manual positioning stage, or a fixed top plate.

The Mobile HomeCage eliminates the need for anesthesia, preserving full physiological functioning of the brain. It provides a natural, tangible environment, which alleviates the stress experienced by rodents during experiments under standard head-fixation conditions.


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GLOSSARY
optogenetics
A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of cells...
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