The DM LFSA microscope from Leica Microsystems Inc. provides a stable platform for patch clamp techniques in live-cell research. The device has a programmable nosepiece for smooth transition from one objective to the next. Multiple probes and manipulation tools can be accessed without adjusting the instrument or disturbing the specimen. Its ceramic dual stage offers thermal protection to the sample while reducing electrical interference. The DM LFSA features long-working-distance water immersion objectives that allow a single set of objectives to create high- performance imaging from 340 to 1000 nm.