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Imaging Cells in Flow
Fluorescence microscopy enables the study of cells with molecular specificity and subcellular resolution. Despite recent improvements in the brightness of fluorescent labels and in the sensitivity of image sensors, imaging is usually limited to stationary cells. Imaging fluorescence in moving cells is fundamentally challenging because the exposure...
8/20/2014
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Design of Long Working Distance Graded-index Fiber Lens With a Low NA for Fiber-Optic Probe in OCT Application
A fiber-optic probe for optical coherence tomography (OCT) applications typically includes a short section of graded index (GRIN) fiber fused onto a single-mode (SM) fiber. The GRIN fiber acts as a lens to focus the output of the SM fiber and to collect the reflected light from the sample. In this paper we will use the beam propagation method...
7/1/2014
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Narrow Line Diode Stacks for DPAL
Diode pumped alkali metal vapor lasers (DPALs) offer the promise of scalability to very high average power levels while maintaining excellent beam quality, making them an attractive candidate for future defense applications. A variety of gain media are used and each requires a different pump wavelength: near 852nm for cesium, 780nm for rubidium,...
7/1/2014

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Time-Lapse Imaging with Lamp and LED – Stability vs Repeatability
Advancements in LED technology today enable LEDs to provide a compelling alternative to lamps for fluorescence microscopy illumination and have become increasingly popular. This article discusses the differences in stability between Lamps and LEDs, and explains the importance of repeatability versus stability when comparing images taken between...
11/17/2014
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Absorption / Transmission / Reflection Spectroscopy
Ultraviolet Visible Near-Infrared (UV-Vis-NIR) spectroscopy is useful to characterize the absorption, transmission, and reflectivity of a variety of technologically important materials, such as pigments, coatings, windows, and filters. This more qualitative application usually requires recording at least a portion of the spectrum for...
11/6/2014

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Hyphenated Raman - OCT Clinical Diagnosis of Skin Cancers
Hyphenated optical techniques combine different measurement modalities in the one instrument to provide a more comprehensive set of complimentary information for carrying out medical diagnosis. This note describes how Raman Spectroscopy (RS) and Optical Coherence Tomography (OCT) have been combined into one instrument to provide a portable machine...
11/6/2014
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Simultaneous Intensity Profiling of Multiple Laser Beams Using the BladeCam-XHR Camera
There are several applications where the parallel processing of multiple beams can significantly decrease the overall time needed for the process. Intensity profile measurements that can characterize each of those beams can lead to improvements in that application. If each beam had to be characterized individually, the process would be very time...
9/26/2014
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Use of White Light Fluorescence LED in long-term Live Cell Imaging Applications
Lamps have long been used in microscopy facilities to conduct time-lapse imaging experiments. Light uniformity, stability and sample exposure are key in generating reliable data. In this study, we evaluate an LED system (X-Cite® 120LED) for our high-content time-lapse experiments and show that LEDs provide a better solution for imaging live cells...
9/4/2014

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Line Scan Cameras Enable High Speed Inspection of Color Filters Within Flat-Panel Display
The market of flat-panel displays (FPD) is a nearly $100 billion business that needs efficient automated optical inspection (AOI) to meet rising demand and remain cost effective. The color filters within the display represent a major inspection task, demanding both precision and speed. Inspection systems using high-speed, high-resolution line...
9/1/2014
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Reduction of Substrate Thermal Damage Using Pulsed UV LED Curing Systems
UV LED curing systems deliver narrow bandwidth, high intensity UV light for low heat, rapid curing of optically-activated materials. Although LED curing systems do not deliver unwanted IR or visible light, some UV-absorbing substrates may still experience heating damage. This white paper demonstrates a novel method to reduce heat damage in...
8/22/2014

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Development of a Virus Biosensor for the Detection of Single Virus Particles - Focussing specifically on the human Norovirus
Recently, biosensors for the detection of viral pathogens have attracted a lot of interest. The rapid identification of the presence of a virus in contaminated food or water or in a patient's sample is a prerequisite to efficiently counteract viral outbreaks, epidemics or bioterrorism.
8/20/2014
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Spatial Light Interference Microscopy
Spatial light interference microscopy (SLIM) is a highly sensitive quantitative phase imaging method, which is capable of unprecedented structure studies in biology and beyond. SLIM combines two classical ideas in optics and microscopy: Zernike's phase contrast method, by revealing the intrinsic contrast of transparent samples, and Gabor's...
8/20/2014

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Light Sheet Microscopy - The Development of the Nervous System
The entire development of the nervous system can now be viewed with excellent temporal resolution using the exceptional capture rate of the Neo sCMOS combined with the Light Sheet Microscopy technique.
8/20/2014
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Diagnosis of Skin Tumors During Mohs Micrographic Surgery
Automated imaging and objective diagnosis of excised tissue specimens during cancer surgery is a promising approach for increasing the efficiency of the most advanced surgical procedure. Firstly, this quantitative approach can increase the efficacy of surgery by eliminating the errors related to the subjective inter-observer evaluation of...
8/8/2014
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How to Use Imaging Colorimeters for FPD Automated Optical Inspection
The use of imaging colorimeter systems and analytical software to assess display brightness and color uniformity, contrast, and to identify defects in FPDs is well established. A fundamental difference between imaging colorimetry and traditional machine vision is imaging colorimetry's accuracy in matching human visual perception for light and...
7/22/2014



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