SANTA CLARA, Calif., May 7, 2008 -- Agilent Technologies Inc. has introduced a multiwavelength laser combiner developed to work with laser-based tools for microscopy applications including epifluorescence, laser scanning confocal and flow cytometry.

The combiner provides 19 wavelength options that can be used in three-channel to eight-channel configurations. As research needs change, new laser wavelength channels can be added, or laser lines can be changed within channel, the company said.

"The Agilent multiwavelength laser combiner offers researchers flexibility not currently available for microscopy platforms," said Bill Volk, Agilent general manager, Nano Positioning Metrology Div. "Existing combiners lock users into a fixed set of wavelengths, which limits flexibility. Users are forced to rework their systems to support new wavelength requirements. Our design allows users to upgrade their system and easily add new wavelength options as their application needs change."

The combiner gives new options to a variety of OEM and end-user applications for fluorescence microscopy, including FRET, TIRF, FLIM, FRAP and FISH (Förster resonance energy transfer, total internal reflection fluorescence, fluorescence lifetime imaging microscopy, fluorescence recovery after photobleaching, and fluorescence in situ hybridization). It is based on Agilent's complex monolithic optic (CMO) design, which incorporates many individual optical components into one monolithic structure. CMO architectures provide a highly flexible platform and are customizable to meet specific system requirements, and this is the first implementation of a CMO design for microscopy applications, the company said.

The CMO design also offers superior alignment throughout a product's lifetime because the optics are bonded into a single prealigned optical structure. As a result, they do not drift out of alignment due to vibration or fluctuations in ambient temperature -- a key factor in maintaining stable light. In addition, fewer exposed optical surfaces decrease environmental contamination, reducing cleaning and maintenance time, the company said.

Agilent is showcasing a three-channel prototype of the multiwavelength laser combiner in Booth 2310 this week at the Conference on Lasers and Electro Optics (CLEO) at the San Jose Convention Center in San Jose, Calif.

For more information, visit: www.agilent.com/find/optics; e-mail: optics-info@agilent.com

Agilent Technologies Inc.
5301 Stevens Creek Blvd.
Santa Clara CA 95051
Phone: (408) 345-8886
Toll-free: (877) 424-4536
Fax: (408) 345-8474

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