Philipps University
In Germany, researchers at Philipps University in Marburg are
testing a new generation of light microscopes made by Wetzlar-based Leica Microsystems
GmbH, with a resolution well below the diffraction limit. With this new optical
nanoscopy called GSDIM (ground state depletion microscopy followed by individual
molecule return), scientists can achieve resolutions down to 25 nm. The technology
makes it possible to image subcellular structures or protein complexes beyond the
resolving powers of a light microscope. The new technology, for which Leica Microsystems
has been granted an exclusive license, will be tested until September. It enables
observation of molecular processes and true-to-detail imaging of the spatial arrangement
of proteins and other biomolecules in cells.
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