Biophotonics International magazine presents the latest global developments and techniques in the photonics industry to those in the medical and biotechnology fields. For more information, or to request a copy of the latest issue, contact us at biophotonics@laurin.com . To subscribe to Biophotonics International go to the subscription area . APRIL 2005 | CONTENTSFeatures Optical Imaging Pushes Forwardby Susan M. Reiss, Contributing EditorResearchers at the National Institutes of Health are using optical methods as a noninvasive way to study cells and tissue.page 32Optical Transformationsby Dr. Stephen T. Ross, Nikon Instruments Inc.New lenses and light sources expand the traditional techniques for total internal reflection fluorescence microscopy. page 38Light-Delivery and Imaging Technologies Advance PDT Knowledgeby Dr. Stuart Bisland, University of TorontoMultimode imaging and new ways devised to irradiate tissue are moving PDT into more diverse clinical applications. page 44ColumnsBiophotonics Research page 50Mechanical loads influence cardiac muscle wall architecture Getting the local — and whole — picture Self-assembling polymersomes concentrate NIR fluorophores Dual-color analysis improves fluorescence spectroscopy Building a better microchip reader Surface plasmon resonance nanosensors help identify biomarkers for Alzheimer's disease Optical coherence tomography technique improves imaging speed Post Scriptsby Nancy D. LamontagneMore proof of new human speciespage 86DepartmentsEditorialpage 9Company Indexpage 13As We Go To Presspage 15Laser looks for cancer OCT images in vivo plaques Spectroscopy reveals invasive speciesTechnology Solutionspage 16A new phase in confocal microscopy Making software count Laser instrument aids chemotaxis experimentsBiophotonics Newspage 22Contrast found for gold particles CT strips fracture studies to the bone Laser scanning system advances eye research Cell phones used in telemedicine Image retrieval technology investigated for screening for eye disease A new buzz about the way bees use lightFrom the Journals page 30Courses & Shows page 64New to the Market page 68New Media page 83Advertiser Index page 85