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Enabling Subcellular pH Sensing

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Daniel S. Burgess

A team of scientists at Rice University in Houston has reported that gold nanoshells — structures on the order of 100 nm in diameter comprising a nonconducting core and an outer layer of gold — can be functionalized to yield surface-enhanced Raman scattering spectra that indicate the pH level at that site. The investigators propose that the nanoparticles may enable applications in the biosciences based on the real-time sensing of chemical changes at the subcellular level, including the noninvasive identification of cancerous tumors and the monitoring of transplanted tissues for early signs of...Read full article

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    Published: September 2006
    Glossary
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    Basic ScienceFeaturesgold nanoshellsMicroscopynanoRaman scatteringreal-time sensingSensors & Detectors

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